Diatoms embedded, self-assembled carriers for dual delivery of chemotherapeutics in cancer cell lines

Kabir, Anayet; Nazeer, Nauman; Bissessur, Rabin; Ahmed, Marya

doi:10.1016/j.ijpharm.2019.118887

Cited by 19 publications

(11 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, DOX and paclitaxel (PTX) have exhibited synergistic interactions in the treatment of solid tumors when the concentration of DOX is higher than PTX. Notably, DE particles are appropriate for the controlled release of these drugs given their easy synthesis and self-assembly [ 59 ]. Terracciano et al used biofunctionalized diatom nanoparticles (DNPs) for drug loading and release studies of sorafenib, a poorly water-soluble anticancer drug.…”

Section: Diatom-based Nanocarriers In Cancer Therapymentioning

confidence: 99%

Microalgae: therapeutic potentials and applications

et al. 2021

View full text Add to dashboard Cite

Recently, special attention has been paid to marine origin compounds such as carbohydrates, peptides, lipids, and carotenoids, which are extracted from microalgae and have anticancer, anti-inflammatory, antimicrobial (e.g., anti-COVID-19 activity), and antioxidant properties in biomedicine and pharmaceutical biotechnology. In addition, these photosynthetic marine microorganisms have several applications in biotechnology and are suitable hosts for the production of recombinant proteins/peptides, such as monoclonal antibodies and vaccines. Silica-based nanoparticles obtained from diatoms (a microalgae group) are used as drug delivery carriers owing to their biodegradability, easy functionalization, low cost, and simple features compared to synthetics, which make these agents proper alternatives for synthetic silica nanoparticles. Therefore, diatom-based nanoparticles are a viable option for the delivery of anti-cancer drugs and reducing the side-effects of cancer chemotherapy.

show abstract

Section: Diatom-based Nanocarriers In Cancer Therapymentioning

confidence: 99%

Microalgae: therapeutic potentials and applications

et al. 2021

View full text Add to dashboard Cite

show abstract

“…A dual drug chemotherapy is often desired in treatment of resistant tumors; however, the desired outcome, synergistic effect of the drugs in combination becomes a challenge. A diatomaceous earth embedded gel system was developed encapsulating the two drugs in different compartments thus controlling the release rate at optimal molar ratios in vitro (Figure 3) (Kabir et al, 2020). In another classical experiment achieving successful dual drug chemotherapy against colorectal cancer, anticancer agents 5-FU and Curcumin were loaded onto diatom-derived porous SiNP and magnetic bacterial nanowires.…”

Section: Diatoms Si Nanosystemsmentioning

confidence: 99%

“…(B) The drugs were encapsulated in Diatomaceous Earth Microparticles (DEMP) either in siliceous core or in β-CD and Adamantane (β-CD:Ad) micelles. Matrix MetalloProteinases-2 (MMP-2) specific peptide substrate was used as a linker between DEMPs core and βCD:Ad shell for stimuli responsive drug release into tumor tissue (Kabir et al, 2020).…”

Section: Diatoms Si Nanosystemsmentioning

confidence: 99%

Microbial Fabricated Nanosystems: Applications in Drug Delivery and Targeting

Kumar

Karn²

2021

Front. Chem.

View full text Add to dashboard Cite

The emergence of nanosystems for different biomedical and drug delivery applications has drawn the attention of researchers worldwide. The likeness of microorganisms including bacteria, yeast, algae, fungi, and even viruses toward metals is well-known. Higher tolerance to toxic metals has opened up new avenues of designing microbial fabricated nanomaterials. Their synthesis, characterization and applications in bioremediation, biomineralization, and as a chelating agent has been well-documented and reviewed. Further, these materials, due to their ability to get functionalized, can also be used as theranostics i.e., both therapeutic as well as diagnostic agents in a single unit. Current article attempts to focus particularly on the application of such microbially derived nanoformulations as a drug delivery and targeting agent. Besides metal-based nanoparticles, there is enough evidence wherein nanoparticles have been formulated using only the organic component of microorganisms. Enzymes, peptides, polysaccharides, polyhydroxyalkanoate (PHA), poly-(amino acids) are amongst the most used biomolecules for guiding crystal growth and as a capping/reducing agent in the fabrication of nanoparticles. This has promulgated the idea of complete green chemistry biosynthesis of nano-organics that are most sought after in terms of their biocompatibility and bioavailability.

show abstract

“…Cell walls or frustules are composed of amorphous silica [15] so they are known for their main role within the biogeochemical cycling of minerals, as it's the case for silicates that can be integrated into their frustules [16]. These important structures can be harnessed to their flexibility of being incorporated into nanodevices as well as for the bio encapsulation and the delivery of therapeutic molecules [17] [18] [19] [20].…”

Section: Introductionmentioning

confidence: 99%

Diatoms’ Breakthroughs in Biotechnology: <i>Phaeodactylum tricornutum</i> as a Model for Producing High-Added Value Molecules

Dhaouadi¹,

Awwad²,

Diamond³

et al. 2020

AJPS

View full text Add to dashboard Cite

With a world growing in population and nutritional needs, diatoms are considered nowadays as microalgae of a very important potential, thus they are exploited in several fields such as ecology, aquaculture, molecular farming, and pharma nutraceuticals. These coveted microalgae are characterized by their diversity, their high division rates, their complex life cycle, likewise their silicified cell walls named frustules. Thus, diatoms have been used for over a century after proving an efficient production of several molecules including Triacylglycerols (TAGs), H 2 , free fatty acids, vitamins, nutraceuticals, amino acids, proteins, terpenoids, alcohols and carbohydrates like starch, glycogen, and sucrose. Phaeodactylum tricornutum is the most promising diatom exploited to date, especially as a platform of pharmaceutical production. Herein, we expose diatoms' main features that allowed using them for molecular farming. This review exposes likewise, the metabolism and the post-translational modifications (PTMs) of diatoms as well as current tools and challenges for their molecular and metabolic engineering for a more efficient production of valuable molecules. The knowledge on the biology of the diatoms, the molecular tools, and the various transformation methods available demonstrate the potential in biotechnology of these photosynthetic microorganisms. The widely studied P. tricornutum, as a model organism, is a promising diatom for production of valuable metabolites, despite the challenges and issues related to cultivation.

show abstract

Diatoms embedded, self-assembled carriers for dual delivery of chemotherapeutics in cancer cell lines

Cited by 19 publications

References 34 publications

Microalgae: therapeutic potentials and applications

Microalgae: therapeutic potentials and applications

Microbial Fabricated Nanosystems: Applications in Drug Delivery and Targeting

Diatoms’ Breakthroughs in Biotechnology: <i>Phaeodactylum tricornutum</i> as a Model for Producing High-Added Value Molecules

Contact Info

Product

Resources

About

Diatoms embedded, self-assembled carriers for dual delivery of chemotherapeutics in cancer cell lines

Cited by 19 publications

References 34 publications

Microalgae: therapeutic potentials and applications

Microalgae: therapeutic potentials and applications

Microbial Fabricated Nanosystems: Applications in Drug Delivery and Targeting

Diatoms’ Breakthroughs in Biotechnology: &lt;i&gt;Phaeodactylum tricornutum&lt;/i&gt; as a Model for Producing High-Added Value Molecules

Contact Info

Product

Resources

About

Diatoms’ Breakthroughs in Biotechnology: <i>Phaeodactylum tricornutum</i> as a Model for Producing High-Added Value Molecules