Diatoms: a biotemplating approach to fabricating drug delivery reservoirs

Chao, Joshua T.; Biggs, Manus; Pandit, Abhay

doi:10.1517/17425247.2014.935336

Cited by 40 publications

(22 citation statements)

References 58 publications

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“…The existing reports demonstrated the applications of diatom in photonics, optics, biosensing, microfluidics, catalysis, nano‐fabrications and in drug delivery etc. Thus, establishing diatom as an emerging tool innanotechnology . The advantages of using diatom are due to its excellent biocompatibility, nontoxicity, chemical resistivity and mechanical rigidity with large area of micro and nano‐porosity which enhances its drug loading capability for development of new drug delivery systems …”

Section: Figurementioning

confidence: 99%

“…Thus, establishing diatom as an emerging tool innanotechnology. [29][30][31][32][33][34][35] The advantages of using diatom are due to its excellent biocompatibility, nontoxicity, chemical resistivity and mechanical rigidity with large area of micro and nano-porosity which enhances its drug loading capability for development of new drug delivery systems. [35][36][37][38][39] Modification of diatom surface has already been carried out with different organic and inorganic biomaterials which have been reported earlier by our group.…”

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confidence: 99%

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Biofabrication of Diatom Surface by Tyrosine‐Metal Complexes:Smart Microcontainers to Inhibit Bacterial Growth

et al. 2020

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This study explores the potential of a highly biocompatible golden brown algal cell, diatom, as a drug carrier to the bacterial cell. The strong interaction between diatom and bacteria that occur in the microenvironment, lead us to pave the way for exciting new directions where diatom can be used to address several bacterial infections. The surface of diatom frustules was modified with self‐assembled antibacterial aromatic amino acid conjugates, Tyr‐ZnII. Microscopy and spectroscopy observations confirmed the deposition of Tyr‐ZnII over diatom frustules. Diatoms can work as living microcontainers to store the toxic metal (drug) ions and therefore can be utilized as potential drug delivery agents to kill the clinically relevant bacteria. Due to antibacterial property of zinc ions, Tyr‐ZnII conjugates inhibits bacterial growth and diatom frustules were utilized as Tyr‐ZnII carrier for controlled release of zinc to the bacterial cell.

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Section: Figurementioning

confidence: 99%

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confidence: 99%

Biofabrication of Diatom Surface by Tyrosine‐Metal Complexes:Smart Microcontainers to Inhibit Bacterial Growth

et al. 2020

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“…Moreover, beyond the utilization of diatom derived materials as nanocarriers or nanovectors for drugs, frustules architecture bio‐inspires a series of solution for bioengineers design, which is an added value in studying these systems . Regardless these features and the recognition by the Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS) for foods and pharmaceuticals production, diatoms utilization in nanomedicine is still surprisingly undervalued …”

Section: Bioderived Nanostructured Silicamentioning

confidence: 99%

Synthetic vs Natural: Diatoms Bioderived Porous Materials for the Next Generation of Healthcare Nanodevices

Rea¹,

Terracciano²,

Stefano³

2016

Adv Healthcare Materials

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Nanostructured porous materials promise a next generation of innovative devices for healthcare and biomedical applications. The fabrication of such materials generally requires complex synthesis procedures, not always available in laboratories or sustainable in industries, and has adverse environmental impact. Nanosized porous materials can also be obtained from natural resources, which are an attractive alternative approach to man-made fabrication. Biogenic nanoporous silica from diatoms, and diatomaceous earths, constitutes largely available, low-cost reservoir of mesoporous nanodevices that can be engineered for theranostic applications, ranging from subcellular imaging to drug delivery. In this progress report, main experiences on nature-derived nanoparticles with healthcare and biomedical functionalities are reviewed and critically analyzed in search of a new collection of biocompatible porous nanomaterials.

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“…Thus, biotemplating is at the forefront of scientific research. For example, highly sophisticated natural structures (e.g., diatoms) are used as templates to build novel functional materials (Bariana et al, ; Belegratis et al, ; Chao et al, ; Liu et al, ). Of significant importance are recent studies, where cyanobacteria cells (Zhang et al, ) and microalgae (Tao et al, ) were used as bio‐templates, however, not for self‐assembled materials as yet.…”

Section: Self‐assembly Within Spatial Confinementmentioning

confidence: 99%

Scaffold and scaffold‐free self‐assembled systems in regenerative medicine

Thomas

Gaspar

Sorushanova

et al. 2015

Biotech & Bioengineering

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Self-assembly in tissue engineering refers to the spontaneous chemical or biological association of components to form a distinct functional construct, reminiscent of native tissue. Such self-assembled systems have been widely used to develop platforms for the delivery of therapeutic and/or bioactive molecules and various cell populations. Tissue morphology and functional characteristics have been recapitulated in several self-assembled constructs, designed to incorporate stimuli responsiveness and controlled architecture through spatial confinement or field manipulation. In parallel, owing to substantial functional properties, scaffold-free cell-assembled devices have aided in the development of functional neotissues for various clinical targets. Herein, we discuss recent advancements and future aspirations in scaffold and scaffold-free self-assembled devices for regenerative medicine purposes. Biotechnol. Bioeng. 2016;113: 1155-1163. © 2015 Wiley Periodicals, Inc.

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Diatoms: a biotemplating approach to fabricating drug delivery reservoirs

Cited by 40 publications

References 58 publications

Biofabrication of Diatom Surface by Tyrosine‐Metal Complexes:Smart Microcontainers to Inhibit Bacterial Growth

Biofabrication of Diatom Surface by Tyrosine‐Metal Complexes:Smart Microcontainers to Inhibit Bacterial Growth

Synthetic vs Natural: Diatoms Bioderived Porous Materials for the Next Generation of Healthcare Nanodevices

Scaffold and scaffold‐free self‐assembled systems in regenerative medicine

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