Diastology 2010: clinical approach to diastolic heart failure

Yamada, Hirotsugu; Klein, Allan L.

doi:10.1007/s12574-010-0055-8

Cited by 13 publications

(9 citation statements)

References 59 publications

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“…Loading conditions, such as changes in preload, could have different effects on early and annular tissue velocities. E velocity is more load dependent and influenced by both myocardial relaxation and LA pressure but E' velocity declines as diastolic dysfunction worsens [11]. In our study E' velocity remains within normal limits but with significant decline in comparison with normal control group and it is compatible with the results of previous studies representing that there will be no global LV diastolic dysfunction till late stage of disease [12,13].…”

Section: Discussionsupporting

confidence: 91%

Value of speckle tracking echocardiography for detection of clinically silent left ventricular dysfunction in patients with β-thalassemia

et al. 2017

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Speckle tracking echocardiography could be used as a feasible method for evaluating subclinical myocardial dysfunction in patients with thalassemia major. Echocardiography, using GLS, could predict clinically silent myocardial dysfunction independent of CMR (T2 * value) and extension of iron deposition. Our study also puts forward other causes such as chronic tissue hypoxia resulting from chronic anemia as a root cause and initiating factor for subsequent injury by the iron deposition. Speckle tracking can recognize the cardiac involvement in really early stages.

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Section: Discussionsupporting

confidence: 91%

Value of speckle tracking echocardiography for detection of clinically silent left ventricular dysfunction in patients with β-thalassemia

et al. 2017

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“…However, right heart catheterization is an invasive procedure and therefore it is usually replaced by echocardiography in clinical practice. With this latter method, filling pressure and modifications of heart structure can be estimated [10,11,12]. …”

Section: Clinical Commentmentioning

confidence: 99%

Sacubitril/Valsartan in an Elderly Patient with Heart Failure: A Case Report

et al. 2017

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Sacubitril/valsartan has recently been approved for the treatment of heart failure with reduced ejection fraction. Given its recent introduction in the armamentarium for the treatment of heart failure (HF), “field-practice” evidence is required to deepen the clinical management of sacubitril/valsartan therapy. We report a relevant case of an elderly patient who achieved major clinical benefits after only 3 months of sacubitril/valsartan therapy. Importantly, in our assessment, we employed speckle tracking echocardiography (STE), a recent echocardiography technique that is non-Doppler and not angle dependent, which analyzes deformations of heart chambers from standard images and allows a fast, reliable, and reproducible assessment of heart function. After 3 months of therapy, NHYA class decreased from III to I-II and hypertension was controlled. Echocardiography examination also showed a marked improvement, with a reduction of left ventricular diameter, improved diastolic function (E = 0.39 m/s; A 0.69 m/s; E/A 0.55), normalized diastolic function index (E/E' TDI = 6.93), normalized atrial volume (63 mL), and improved atrial strain (15.44%). This case report documents the fast clinical and symptom improvement with sacubitril/valsartan in an elderly patient with HF; comprehensive echocardiographic assessment, including STE, also revealed a marked functional improvement with this compound.

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“…There is still today an ongoing debate about whether true diastolic dysfunction really exists [15,18]. The abovedescribed patient case is a relatively typical patient that could be diagnosed with primary diastolic dysfunction with hypertrophic myocardium secondary to the increased afterload due to the progressive aortic stenosis.…”

Section: Primary Diastolic Dysfunction?mentioning

confidence: 99%

How should we measure global and regional left ventricular systolic function?

Sahlén

Winter

2011

J Echocardiogr

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The assessment of left ventricular (LV) systolic function is frequently the most important task during the echocardiography examination. LV ejection fraction (EF) is the most commonly used measure to assess LV systolic function. EF is well established, with strong prognostic and therapeutic implications, but, nevertheless, it may not always be satisfactory in all patients. Other measures of myocardial contractility can provide valuable additive information in some patients. This is particularly true in patients with suspected heart failure but normal EF. The measurement of longitudinal function using M-mode and/or deformation analysis from tissue Doppler data or speckle tracking algorithms can be useful in this respect. Regional LV dysfunction can be difficult to detect using visual semi-quantitative assessment of regional wall motion. Contrast echocardiography can be most helpful in delineating the LV endocardial border and, thus, increasing sensitivity for detecting wall motion abnormalities. Deformation analysis can also be helpful for detecting subtle wall motion abnormalities, but these methods should be used with caution due to measurement variability and image quality dependence.

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Diastology 2010: clinical approach to diastolic heart failure

Cited by 13 publications

References 59 publications

Value of speckle tracking echocardiography for detection of clinically silent left ventricular dysfunction in patients with β-thalassemia

Value of speckle tracking echocardiography for detection of clinically silent left ventricular dysfunction in patients with β-thalassemia

Sacubitril/Valsartan in an Elderly Patient with Heart Failure: A Case Report

How should we measure global and regional left ventricular systolic function?

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