Diastolic Function and Ambulatory Hypertension in Children With Chronic Kidney Disease

Mitsnefes, Mark; Xu, Yunwen; Ng, Derek K.; Kimball, Thomas R.; Furth, Susan L.; Warady, Bradley A.

doi:10.1161/hypertensionaha.121.17449

Cited by 10 publications

(3 citation statements)

References 41 publications

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“…Moreover, an increase in E/E’AVG might reflect elevated LV filling pressures due to abnormal relaxation patterns [ 57 ]. Hence, E/E’AVG can further be used for the estimation of myocardial compliance at end-diastole [ 58 ]. The significantly increased E/E’AVG ratio within the ART subjects of ≥ 10 years of age might be compensated for through an increase in atrial pressure over the life span, visualized by the relative elevation in A.…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies

Sciuk

Vilsmaier

Kramer

et al. 2022

JCM

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Subjects conceived through assisted reproductive technologies (ART) potentially suffer from impaired left ventricular (LV) function due to premature vascular aging. This study aimed to evaluate whether subtle differences in LV diastolic function can be observed echocardiographically between young ART subjects and their spontaneously conceived peers. The echocardiographic assessment included the measurement of LV dimensions, mitral inflow velocities, and myocardial velocity at early diastole (E’, cm/s) at the LV wall and the interventricular septum (IVS). An average from E/E’LV and E/E’IVS (E/E’AVG) was derived. In total, 66 ART subjects and 83 controls (12.85 ± 5.80 years vs. 13.25 ± 5.89 years, p = 0.677) were included. The ART subjects demonstrated a significantly lower E’LV (19.29 ± 3.29 cm/s vs. 20.67 ± 3.78 cm/s, p = 0.020) compared to their spontaneously conceived peers. Study participants of ≥ 10 years of age displayed a significantly higher E/E’AVG (6.50 ± 0.97 vs. 6.05 ± 0.99, p = 0.035) within the ART cohort. The results of this study demonstrate a significantly lower LV diastolic function in the ART subjects. However, no significant changes in LV diastolic function were observed between the two groups when the results were adjusted for age, birth weight percentile, and gestational age. Those ART subjects born preterm might have an elevated risk of developing LV diastolic alterations and could therefore profit from close echocardiographic monitoring.

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Section: Discussionmentioning

confidence: 99%

Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies

Sciuk

Vilsmaier

Kramer

et al. 2022

JCM

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“…This is consistent with previous studies in both adults and children showing that ABP is a superior predictor of individual clinical and intermediate cardiovascular outcomes. [23][24][25][26][27] A recent study from the International Childhood Cardiovascular Cohort (i3C) Consortium found that a combined risk score comprised of several traditional cardiovascular risk factors better predicted cardiovascular events adulthood than each risk factor by itself. 28 In that study, 20,656 participants who had cardiovascular risk factors measured in childhood had their vital status ascertained in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Ambulatory Blood Pressure and Number of Subclinical Target Organ Injury Markers in Youth: The SHIP AHOY Study

Hamdani,

Urbina,

Daniels

et al. 2024

Preprint

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Background: Hypertension in adolescence is associated with subclinical target organ injury (TOI). We aimed to determine whether different blood pressure (BP) thresholds were associated with increasing number of TOI markers in healthy adolescents. Methods: 244 participants (mean age 15.5±1.8 years, 60.1% male) were studied. Participants were divided based on both systolic clinic and ambulatory BP (ABP), into low- (<75th percentile), mid- (75th-90th percentile) and high-risk (>90th percentile) groups. TOI assessments included left ventricular mass, systolic and diastolic function, and vascular stiffness. The number of TOI markers for each participant was calculated. A multivariable general linear model was constructed to evaluate the association of different participant characteristics with higher numbers of TOI markers. Results: 47.5% of participants had at least one TOI marker: 31.2% had one, 11.9% two, 3.7% three, and 0.8% four. The number of TOI markers increased according to the BP risk groups: the percentage of participants with more than one TOI in the low-, mid-, and high groups based on clinic BP was 6.7%, 19.1%, and 21.8% (p=0.02), and based on ABP was 9.6%, 15.8%, and 32.2% (p<0.001). In a multivariable regression analysis, both clinic BP percentile and ambulatory SBP index were independently associated with the number of TOI markers. When both clinic and ABP were included in the model, only the ambulatory SBP index was significantly associated with the number of markers. Conclusion: High SBP, especially when assessed by ABPM, was associated with an increasing number of subclinical cardiovascular injury markers in adolescents.

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“…The G-395A polymorphism has a mutant allele denoted by A. [32] Those with chronic kidney disease (both those on conservative treatment and those on hemodialysis) had substantially higher frequencies of the GA + AA genotype compared to children without CKD. The frequencies of the G and A alleles were also significantly different.…”

Section: Discussionmentioning

confidence: 99%

Klotho G-395A Gene Polymorphism: Impact on Progression of End-Stage Renal Disease and Development of Cardiovascular Complications in Children on Dialysis

M. Ezzat,

R. Soliman,

A. Elsayed

et al. 2024

Benha Journal of Applied Sciences

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Background: at In recent years, many indicators have been identified that may predict the likelihood of chronic kidney disease in children who already have certain risk factors. But it's still not easy to accurately measure danger. Goal: This research set out to examine the relationship between cardiovascular problems in juvenile patients on hemodialysis for end-stage renal illness and klotho gene polymorphisms (G-395A). Procedures and Materials: Fifty children participated in the case control study; twenty were on maintenance hemodialysis for end-stage renal disease, ten were on conservative therapy for chronic kidney disease, and ten were healthy controls. All forty kids were genotyped for Klotho G-395A and evaluated for clinical and echographic variants. Findings: Compared to control children, children with chronic kidney disease (both conservative and hemodialysis patients) had much higher frequencies of the GA + AA genotype. The frequencies of the G and A alleles were also significantly different. When looking at the two groups side by side, we can see that the GG and GA+AA frequencies were significantly different between the control and hemodialysis groups, but not between the conservative and hemodialysis groups. On the other hand, the AA genotype frequency was significantly different between the conservative and control groups, as well as between the hemodialysis and control groups. In conclusion, CKD risk factors increased the likelihood of development in children carrying the AA or GA genes, which are examples of wild genes.

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Diastolic Function and Ambulatory Hypertension in Children With Chronic Kidney Disease

Cited by 10 publications

References 41 publications

Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies

Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies

Ambulatory Blood Pressure and Number of Subclinical Target Organ Injury Markers in Youth: The SHIP AHOY Study

Klotho G-395A Gene Polymorphism: Impact on Progression of End-Stage Renal Disease and Development of Cardiovascular Complications in Children on Dialysis

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