Diastereoselective synthesis of novel 2,5-dioxopyrrolidine derivatives via biocatalytic domino reactions

Abstract

A series of novel 2,5-dioxopyrrolidines were synthesized by the one-pot reaction of coumarin-3-carboxylic acids 1 with thiourea derivatives and alkyl isocyanides in the presence of Fe 3 O 4 NPs @ lipase as heterogeneous reusable nanobiocatalysts with high yields.

Fe3O4@SiO2@D‐NHCS‐Tr as an efficient and reusable catalyst for the synthesis of indol‐3‐yl‐4H‐chromene via a multi‐component reaction under solvent‐free conditions

“…As a result of these observations and in following of our previous work on the synthesis of heterocyclic compounds in the presence of catalyst [37][38][39][40][41][42][43][44][45][46][47], we want to report an effective and green method for the synthesis of indol-3-yl-4H-chromene derivatives using Fe 3 O 4 @SiO 2 @D-NHCS-Tr [37] reusable and heterogeneous nanobiocatalysts.…”