Diastereoselective synthesis ofcis-1,3-disubstituted isoindolinesviaa highly site-selective tandem cyclization reaction

Abstract

A highly site-selective tandem reaction involving regioselective ring opening of aziridines and Michael addition of electron-deficient alkenes has been described.

Diastereoselective Construction of 2-Aminoindanones via an In(OTf)3-Catalyzed Domino Reaction

“…However, domino reactions that simultaneously involves ring opening of aziridines and Michael addition were rarely reported in the literature . In 2016, we designed and synthesized a type of substrates containing aziridines and electron-deficient alkenes . Secondary amines and primary amines were first selected as nucleophiles to initiate domino reactions of this kind of substrates under the catalysis of AgOTf .…”