Diastereoselective synthesis of chroman bearing spirobenzofuranone scaffolds via oxa-Michael/1,6-conjugated addition of para-quinone methides with benzofuranone-type olefins
Abstract:Highly diastereoselective synthesis of spirocyclic compounds combining both well-known heterocyclic pharmacophores chroman and benzofuran-2-one.
The unique reactivity of indolyl-substituted p-QMs as a new type of two-carbon synthons has been explored for the first time in a novel tandem annulation. This (2+2) annulation/retro-4π electrocyclization/imino-Nazarov cyclization...
The unique reactivity of indolyl-substituted p-QMs as a new type of two-carbon synthons has been explored for the first time in a novel tandem annulation. This (2+2) annulation/retro-4π electrocyclization/imino-Nazarov cyclization...
Here, we demonstrate that the first example of harmaline scaffolds serving as acceptor/acceptor-based N-C-C synthons-triggered the ring opening and skeletal reconstruction of 3-vinyl benzofuranones for the construction of a library...
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