Diastereoselective Synthesis and Antifungal Activity of Glycosyl Isoxazolines

Mishra, Rupesh K.; Tewari, Neetu; Verma, Shyam S.; Tripathi, Rama Pati; Kumar, Manish; Shukla, Praveen Kumar

doi:10.1081/car-200037331

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Antiviral and Antifungal Aminoalkyl Gluco-furanoses And Glyc1

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Cited by 15 publications

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“…Another series, starting with galacto-pyranosyl oxime (116) was also prepared and the compounds were evaluated for their antifungal activity, where some of these glycosyl isoxazolines were shown promising activity (Fig. 19) [108].…”

Section: Antiviral and Antifungal Aminoalkyl Gluco-furanoses And Glycmentioning

confidence: 99%

Spirocyclic Nucleosides in Medicinal Chemistry: An Overview

Soengas

Silva²

2012

MRMC

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Section: Antiviral and Antifungal Aminoalkyl Gluco-furanoses And Glycmentioning

confidence: 99%

Spirocyclic Nucleosides in Medicinal Chemistry: An Overview

Soengas

Silva²

2012

MRMC

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Practical TEMPO-Mediated Oxidation of Alcohols using Different Polymer-Bound Co-Oxidants

Kloth¹,

Brünjes²,

Kunst³

et al. 2005

Advanced Synthesis & Catalysis

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Hypochlorite and chlorite exchange resins are evaluated as co-oxidants or oxidants, respectively, for the oxidation of alcohols to the corresponding aldehydes, ketones or carboxylic acids. Polymer-bound hypochlorite can act as a co-oxidant in TEMPOmediated oxidations of alcohols. The formation of aldehydes only works under weakly acidic conditions. However, the cheap hypochlorite exchange resin is less efficient as co-oxidant compared to the use of ionically immobilised bisacetoxybromate(I) anions. In contrast, the chlorite exchange resin is a highly potent co-oxidant for the preparation of carboxylic acids from the corresponding primary alcohols in the presence of TEMPO. It is demonstrated that in this case also the resin acts as a polymer-bound co-oxidant for both oxidation steps. Yields are commonly excellent as is also demonstrated for examples taken from natural product synthesis which include acid labile glycosides. In most cases, work-up of this heavy metal-free oxidation is kept to a minimum. It often includes filtration followed by removal of the solvent.

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