Diastereoselective Hydrogenation

Abstract

In the hydrogenation of alkenes, rhodium-, ruthenium-and iridium-phosphine catalysts are typically used [2][3][4]. Rhodium-phosphine complexes, such as Wilkinson's catalyst, are effective for obtaining alkanes under atmospheric pres- 631The Handbook of Homogeneous Hydrogenation. Edited by J. G. de Vries and C. J. Elsevier

Bis(phosphine)cobalt Dialkyl Complexes for Directed Catalytic Alkene Hydrogenation

“…Homogeneous alkene hydrogenation catalysts, unlike their heterogeneous counterparts, offer the opportunity to promote site selective reactions through rational ligand design . Among these, directed hydrogenations where the interaction of a functional group in the substrate with the catalyst imparts high levels of stereocontrol have found widespread application in synthesis due to the ability to access products with contrasteric selectivity. − Wilkinson’s, Schrock–Osborn-type, and Crabtree’s catalysts, (Ph 3 P) 3 RhCl, [(P–P)­Rh­(COD)] + , and [Ir­(COD)­(py)­(PCy 3 )] + (COD = 1,5-cyclooctadiene, py = pyridine, Cy = cyclohexyl), respectively, have been the most widely used due to their high activity, selectivity, ease of handling, and availability.…”