Diaschisis Resulting From Acute Unilateral Cerebral Infarction

Meyer, John Stirling; Shinohara, Yukito; Kanda, Tadashi; Fukuuchi, Yasuo; Ericsson, Arthur Dale; Kok, Norma K.

doi:10.1001/archneur.1970.00480270051007

Cited by 153 publications

(36 citation statements)

References 16 publications

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“…While the flow in the control hemisphere in the same animal appeared a little lower than one might have expected, it was not significantly different from control values in a larger previous group of animals, and thus there was no confident evidence of the phenomenon of diaschisis which has been referred to by other workers. 27 ' 28 To obtain evidence on this point, however, it would be necessary to make many more recordings over the normal hemisphere in infarcted animals which, for technical reasons, was not found particularly easy in the present series. In the hemisphere containing the infarct, however, the general picture was of reduced blood flow.…”

Section: Co Mactivitymentioning

confidence: 83%

Local Cerebral Blood Flow and Vascular Reactivity in a Chronic Stable Stroke in Baboons

Symon

Crockard

Dorsch

et al. 1975

Stroke

104

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Blood flow in the hemispheres of baboons three years after middle cerebral artery occlusion has been assessed by the hydrogen clearance technique. Blood flow in the infarct itself varied from very low (8 ml/100 gm per minute) to very high (89 ml/100 gm per minute) values and, averaging the values for the infarct as a whole, it was impossible to distinguish average flows in the infarct from those of the normal hemisphere. Flow values in surrounding zones of the infarct remained significantly lower than those of comparable normal hemispheres, and, excluding the infarct, the mean average hemispheral blood flow was 35.2 ml/100 gm per minute. This indicates a significant reduction in flow in the cortex, subsequently shown histologically to be normal, compared with normal blood flow values for the baboon hemisphere. Autoregulation was lost in the infarct and impaired in surrounding tissue. CO 2 reactivity was grossly reduced in the hemisphere as a whole but was present in all areas, even occasionally in electrode placements within the infarct itself. After perfusion fixation of the head, pathological study of the area of infarction showed a fairly consistent distribution, the infarct itself consisting of many dilated blood vessels of non-capillary nature scattered among fibrous tissue in what was virtually a glial scar.

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Section: Co Mactivitymentioning

confidence: 83%

Local Cerebral Blood Flow and Vascular Reactivity in a Chronic Stable Stroke in Baboons

Symon

Crockard

Dorsch

et al. 1975

Stroke

104

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“…In humans, after unilateral infarction, the EEG has demonstrated both bilateral slowing 45 and ipsilateral slowing with no change contralaterally. 46 In patients with either a unilateral tumor or stroke evaluated more than 2 weeks after injury (or after diagnosis), the majority showed an increase in contralateral SEP amplitude (N22 component) compared to controls, regardless of whether a sensory deficit was present or not.…”

Section: Subacute Intermediate and Chronic Time Periodsmentioning

confidence: 99%

Transhemispheric diaschisis. A review and comment.

Andrews

1991

Stroke

229

141

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“…Modifications of the electrical activity (Buchkremer-Ratzmann et al, 1996;Meyer et al, 1970;Witte and Stoll, 1997), cerebral blood flow (Andrews, 1991;Dobkin et al, 1989), and/or metabolism (Andrews, 1991;Kuhl et al, 1980) have been reported at the cortical level (diaschisis), mainly within areas mirror to the lesion. In animal models of cerebral ischemia, Izumi et al (2002) recently reported a progressive edema in both hemispheres within the first few hours after MCA occlusion in rats.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Diffusion Changes in Cerebral Hemispheres after MCA Infarcts

Buffon

Molko

Hervé

et al. 2005

J Cereb Blood Flow Metab

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Diffusion tensor imaging can be used in vivo to assess the longitudinal and regional microstructural changes occurring after middle cerebral artery (MCA) infarcts in humans. Nine patients were investigated 1 week (D7), 1 (M1), 3 (M3), and 6 months (M6) after the occurrence of an isolated MCA infarction. First, an overall analysis was performed using histograms of mean diffusivity (MD) and fractional anisotropy (FA) in each hemisphere. Thereafter, the regional pattern of diffusion changes was investigated voxel by voxel with statistical parametric mapping 99. In the hemisphere ipsilateral to the infarction, histogram analysis revealed a significant decrease in FA between D7 and M6 associated with a progressive increase in MD from D7 to M3. Remote from the MCA territory, the voxel by voxel analyses detected a significant increase in MD within the thalamus at M3 and M6 and a reduction in FA along the pyramidal tract at M6. In the contralateral hemisphere, between D7 and M6, a significant hemispheric atrophy was observed in association with a global reduction in anisotropy, in the absence of distinctive regional diffusion changes. These results suggest that micro-and macrostructural tissue modifications can be detected with diffusion tensor imaging in regions remote from the ischemic area in both hemispheres.

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Diaschisis Resulting From Acute Unilateral Cerebral Infarction

Cited by 153 publications

References 16 publications

Local Cerebral Blood Flow and Vascular Reactivity in a Chronic Stable Stroke in Baboons

Local Cerebral Blood Flow and Vascular Reactivity in a Chronic Stable Stroke in Baboons

Transhemispheric diaschisis. A review and comment.

Longitudinal Diffusion Changes in Cerebral Hemispheres after MCA Infarcts

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