Diaschisis in Cerebral Mitochondrial Disorder

Narla, Vinod V.; Muthukrishnan, Ashok; Mountz, James M.

doi:10.1097/rlu.0b013e31817dec3c

Cited by 5 publications

(1 citation statement)

References 13 publications

(8 reference statements)

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“…Diagnosis of mitochondrial dementia requires neuropsychological testing, cerebrospinal fluid investigations, visually-evoked potentials, EEG, brain CT and MRI scans, phosphorus or proton-magnetic resonance spectroscopy, SPECT, or positron emission tomography with fluorine 18-labeled deoxyglucose (FDG-PET) [18]. High-resolution regional cerebral blood flow obtained through Tc-99m ethylcysteinate dimer SPECT can better localize and assess the extent of brain damage in patients with suspected MD and only subtle changes on MRI [20]. Recently, reduced regional glucose metabolism has been observed in the frontotemporal region of two siblings with mtDNA multiple deletions and a Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)-like disorder, by means of FDG-PET [21].…”

Section: Cognitive Impairment In Mitochondrial Disordersmentioning

confidence: 99%

Mitochondria, Cognitive Impairment, and Alzheimer's Disease

Mancuso

Calsolaro

Orsucci

et al. 2009

International Journal of Alzheimer's Disease

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To date, the beta amyloid (Aβ) cascade hypothesis remains the main pathogenetic model of Alzheimer's disease (AD), but its role in the majority of sporadic AD cases is unclear. The “mitochondrial cascade hypothesis” could explain many of the biochemical, genetic, and pathological features of sporadic AD. Somatic mutations in mitochondrial DNA (mtDNA) could cause energy failure, increased oxidative stress, and accumulation of Aβ, which in a vicious cycle reinforce the mtDNA damage and the oxidative stress. Despite the evidence of mitochondrial dysfunction in AD, no causative mutations in the mtDNA have been detected so far. Indeed, results of studies on the role of mtDNA haplogroups in AD are controversial. In this review we discuss the role of the mitochondria, and especially of the mtDNA, in the cascade of events leading to neurodegeneration, dementia, and AD.

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Section: Cognitive Impairment In Mitochondrial Disordersmentioning

confidence: 99%

Mitochondria, Cognitive Impairment, and Alzheimer's Disease

Mancuso

Calsolaro

Orsucci

et al. 2009

International Journal of Alzheimer's Disease

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Correlation between crossed cerebellar diaschisis and clinical neurological scales

Szilágyi

Vas

Kerényi

et al. 2011

Acta Neurologica Scandinavica

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The Low Frequency Approximation of the Sound Radiation Power of Two Vibrating Circular Pistons Embedded in Two Different Rigid Planes of a~Three-wall Corner

Rdzanek

Szemela

2014

Acta Phys. Pol. A

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The problem of sound radiation by a system consisting of two vibrating circular pistons embedded in two of three dierent planes perpendicular to one another forming a three-wall corner is considered. The earlier published results dealing with the sound radiation by sources vibrating in a three-wall corner are the basis of analysis. According to the earlier studies, the exact formulae for acoustic power of radiation of two circular pistons are used. The formulae are expressed as double Fourier integrals. The active and reactive, self and mutual, components are separated from them as well as the corresponding expressions of the acoustic power of mirror images of the piston sources. The acoustic power of the two sources are expressed in the form of the Rayleigh formulae whereas, in the case of the mirror images, it is expressed in the form of the single series expansion containing spherical Bessel and Neumann functions. In the case of the mutual acoustic power of the sources, approximate formulae are presented for low frequencies. On the basis of the results obtained, the corresponding formulae valid for a two-wall corner are presented as the limiting transitions. All the results presented can be useful, e.g. in designing the room acoustics and outdoor system everywhere the free eld conditions are disturbed by the acoustic waves reected at rigid vertical walls for the wavelengths being considerably shorter than the geometric sizes of the walls.

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Diaschisis in Cerebral Mitochondrial Disorder

Cited by 5 publications

References 13 publications

Mitochondria, Cognitive Impairment, and Alzheimer's Disease

Mitochondria, Cognitive Impairment, and Alzheimer's Disease

Correlation between crossed cerebellar diaschisis and clinical neurological scales

The Low Frequency Approximation of the Sound Radiation Power of Two Vibrating Circular Pistons Embedded in Two Different Rigid Planes of a~Three-wall Corner

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