Diarylplatinum(II) Compounds as Versatile Metallating Agents in the Synthesis of Cyclometallated Platinum Compounds with N-Donor Ligands

Abstract

This review deals with the reactions of diarylplatinum(II) complexes with N-donor ligands to produce a variety of cycloplatinated compounds including endo-five-, endo-seven-, endo-six-or exo-five-membered platinacycles. The observed reactions result from a series of oxidative addition/reductive elimination processes taking place at platinum(II)/platinum(IV) species and involving C-X (X = H, Cl, Br) bond activation, arene elimination, and, in some cases, C aryl -C aryl bond formation.

Carbon‐iodide bond activation by cyclometalated Pt (II) complexes bearing tricyclohexylphosphine ligand: A comparative kinetic study and theoretical elucidation

“…Platinum (II) complexes provide a useful platform for kinetic and mechanistic studies of fundamental oxidative addition reactions because of their relative inertness, high stability and availability of different oxidation states . Oxidative addition of C–X bonds to platinum (II) complexes is generally enthalpically favored and produces the corresponding platinum (IV) products normally proceeding through a S N 2 type mechanism in which the Pt (II) center acts as a nucleophile via the filled d z 2 orbital . However, a radical pathway as well as concerted three‐center mechanisms have also been suggested for oxidative addition reactions …”

Pt(II) Derivatives with Rollover-Coordinated 6-substituted 2,2′-bipyridines: Ligands with Multiple Personalities

“…Furthermore, the presence of 195 Pt satellites for the H4, H5 and H6′ protons demonstrates that the ligand is still coordinated to platinum center, as well as the DMSO and methyl groups (DMSO: singlet with satellites at δ = 3.29 ppm, 3 JPt-H = 20.3 Hz; methyl: singlet with satellites at δ = 0.76 ppm, 2 JPt-H = 80.8 Hz).…”

“…Cyclometalated complexes constitute an important class of organometallic compounds owing to their intrinsic stability and the wide range of their potential applications [1][2][3]. Among the ample variety of cyclometalated compounds, the so-called rollover complexes constitute a special and intriguing case due to their peculiar properties [4][5][6].…”

Experimental and theoretical investigation of cyclometallated platinum(ii) complex containing adamantanemethylcyanamide and 1,4-naphthoquinone derivative as ligands: synthesis, characterization, interacting with guanine and cytotoxic activity

“…Recently, cyclometallated platinum complexes containing Ndonor ligands have been the object of much research attention due to interest in their biological activities. [1][2][3][4][5][6][7][8][9] The antitumor activity of different platinum(II) complexes is associated with the platination of DNA, generally through binding to guanine. Hence, anticancer platinum(II) complexes have been investigated with guanine derivatives in theoretical and experimental studies and they have shown a high selectivity for binding to N7 of guanine.…”