Diarylpentanoids and phenylpropanoids from the roots of Anthriscus sylvestris (L.) Hoffm

Chemical Constituents with Anti-Proliferative Activity on Pulmonary Arterial Smooth Muscle Cells from the Roots of Anthriscus sylvestris (L.) Hoffm.

“…The cells were divided into the normal group (NC), model group (M), and treatment groups (isolated compounds). Then, the MTT assay was performed as previously described [ 12 ]. All data were analyzed by SPSS software version 26.0 (IBM, New York, NY, USA) and presented as the mean ± standard deviation.…”

“…Fifteen known compounds were identified as bakuchiol (3) [17], 1,3-hydroxybakuchiol (4) [17], 15-demetyl-12,13-dihydro-13-ketobakuchiol (5) [17], 3,2-hydroxybakuchiol (6) [17], 12,13-diolbakuchiol (7) [18], 2,3,4-trimethylbenzylalcohol-O-β-D-glucopyranoside acid (10) [19], p-cymen-7-yloxy-β-D-glucopyranoside (11) [20], methyl di-O-methyl-O-glucosylgallate (12) [15], methyl 4-(β-D-glucopyranosyloxy)-3-methoxybenzoate (13) [21], benzyl α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (14) [16], 2-phenylethyl-β-Dglucopyranoside (15) [22], 3,5-dihydroxyestragole 3-O-β-D-glucopyranoside ( 16) [23], 5-O-feruloylquinic acid methyl ester (17) [24], butyl(4-β-D-glucopyranosyloxy-phenyl)acetate (18) [25], and 3,5-dicaffeoylquinic acid (19) [26].…”

“…Pulmonary vascular remodeling involves a variety of cells, including vascular endothelial cells, pulmonary artery smooth muscle cells (PASMCs), and multiple inflammatory cells [10,11]. The previous study demonstrated that diarylpentanoids and phenylpropanoids isolated from the roots of A. sylvestris could inhibit the abnormal proliferation of PASMCs induced by hypoxia [12], which attracted our interest to search for more natural products with anti-proliferative effects from this plant. In this study, two new nitrogen-containing phenylpropanoids (1-2), and two new phenol glycosides (8)(9), along with fifteen known analogues, were isolated from the roots of A. sylvestris, and their anti-proliferative effects against the abnormal proliferation of pulmonary arterial smooth muscle cells were evaluated.…”

Anthriscus sylvestris—Noxious Weed or Sustainable Source of Bioactive Lignans?

“…In addition to lignans, various other compounds have been identified in A. sylvestris roots, including acyloxycarboxylic acid, phenylpropanoid esters, phenylpropanoids [ 50 , 54 , 56 , 57 , 58 , 59 ], terpenes [ 57 , 60 ], polyynes (polyacetylenes) [ 51 , 52 , 61 ], phytosterols, and fatty acids [ 57 ]. Phytochemical investigations have revealed the presence of anthriscusin, crocatone, and ( Z )-2-angeloyloxymethyl-2-butenoic acid in the hexane root extract [ 56 ], while essential oil analysis showed a rich composition of terpenes such as α-pinene, β-myrcene, d-limonene, p -cymene, and sesquiterpenes [ 57 , 60 ].…”