Diarylheptanoid analogues from the rhizomes ofZingiber officinaleand their anti-tumour activity

Abstract

Diarylheptanoid analogues from the rhizomes of Zingiber officinale and their anti-tumour activity.

Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer

“…It also promoted DNA double-strand break and induced cancer cell apoptosis through multiple pathways ( 44 – 46 ). Curcumin is known to regulate the expression of DNA repair-related genes, inhibit tumor growth, promote apoptosis, and enhance the chemosensitivity of MMR-deficient CRC to 5-FU ( 47 – 49 ). Berberine led to the downregulation of RRM1, RRM2, LIG1, and POLE2, participated in DNA repair and replication, and demonstrated the potential to inhibit DNA repair ( 50 ).…”

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

“…Raut developed a synthetic route for the preparation of isomeric macrolides of combretastatin D congeners called 11-O-methylcorniculatolide A (5), isocorniculatolide A (7), and 11-O-methylisocorniculatolide A (8), where the key steps comprised an S N Ar reaction for the diaryl ether formation and a Mitsunobu reaction for the macrolide formation [69]. Thus, the S N Ar reaction between the ester 155 and the aldehyde 156 led to the formation of diaryl ether 157 which was subjected to a hydrogenation reaction followed by hydrolysis of the ester group to yield the corresponding seco-acid 159.…”

“…More recently, cyclic diaryl ether heptanoids (DAEH) [5], another class of macrocycles has been attracting attention not only because of their structural and stereochemical characteristics, but also for shown biological activities, with potential therapeutic application [6][7][8][9][10][11][12]. Examples of this class of compounds are the combretastatin D series [13] and their analogues, corniculatolides and isocorniculatolides [14], which are struc-turally characterized as an oxa [1.7]meta-paracyclophane framework.…”

Recent Advances in the Synthesis of Diarylheptanoids

“…Since the discovery of curcumin in 1815 by Vogel and Pelletier [1][2] diarylheptanoids have been thoroughly investigated due to their unique architectural features as well as their broad range of biological activities. [3][4][5][6][7] This class of compounds have been found to exhibit antiinflammatory, [8] antioxidant, [9] anticancer, [10][11] antiviral, [12] hepatoprotective [13] and neuroprotective activities. [14] Based on the type of seven carbon unit present between the two aryl rings, diarylheptanoids are being classified into four subgroups, namely linear diarylheptanoids (LDH) (I), tetrahydropyran diarylheptanoids (THPDH) (II) containing a THP ring in the sevencarbon chain, diarylether heptanoids (DAEH) (III) with aryl-aryl ether bond and biphenyl diarylheptanoids (BPDH) (IV) with a biphenyl bridge (Figure 1A).…”