Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation

Feasible Synthesis of the GPR40 Antagonist by Constructing 2-Thiouracil Ring via Acid Mediated Cyclization

“…The latter acid 6 was treated with oxalyl chloride in the presence of a drop of DMF to provide the acid chloride 7 13, 14 . The acid chloride 7 was then coupled with KSCN to give the corresponding isothiocyanate derivatives 8 15, 16 .…”

Synthesis, bioactivity, 3D-QSAR studies of novel dibenzofuran derivatives as PTP-MEG2 inhibitors

“…Before the generation of pharmacophore hypotheses, the training set compounds were converted into 3D structure to generate diverse conformations using the Diverse Conformation Generation protocol implemented in Discovery studio v3.5. Per molecule will generate the maximum numbers of 200 conformations to ensure maximum coverage of the conformational space by using Best conformation model generation method with CHARMm force field [32] and Poling algorithm [33–36] module implemented in Discovery studio v3.5 was used to construct pharmacophore model in order to offer promising scaffolds for the development of novel and potent PTP-MEG2 inhibitors. The common feature pharmacophore generation used in this study was obtained by defining two properties-Pincipal and MaxOmitFeat of the ligands in the dataset that determined which molecules should be considered when building the pharmacophore space and which molecules should map to all or some of the features in the final pharmacophore.…”

5-HT2C antagonists based on fused heterotricyclic templates: Design, synthesis and biological evaluation

“…In a previous communication 5 we described a series of compounds exemplified by 1 (Fig. 1) which combine potency at the 5-HT 2C receptor with good selectivity for this target and a favourable profile in vivo.…”