Diarrhœa Caused by Candida

Kane, James G.; Chrétien, J; Garagusi, Vincent F.

doi:10.1016/s0140-6736(76)90087-8

Cited by 39 publications

(15 citation statements)

References 8 publications

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“…In summary, the results of our study do not confirm the previously suggested pathogenetic mechanisms of Candida-related AAD [3,4,6,15]. Our data indicate that elevated Candida counts are a result of antibiotic treatment or diarrhea per se rather than a cause of AAD.…”

Section: Discussioncontrasting

confidence: 99%

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Role of Candida in Antibiotic‐Associated Diarrhea

et al. 2001

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To quantitatively assess the role of Candida species in antibiotic-associated diarrhea (AAD), stool samples from a total of 395 patients and control subjects were cultured in differential isolation medium: 98 patients had AAD, 93 patients were taking antibiotics but did not have diarrhea (A(+)D(-)), 97 patients were not taking antibiotics but had diarrhea (A(-)D(+)), and 107 patients were control subjects (A(-)D(-)). In addition, secreted aspartyl proteinase (Sap) production was tested. In AAD patients, Candida positivity (77/98) and Candida overgrowth (62/98) were not different from that among A(+)D(-) patients (75/93 [P= .860] and 52/93 [P= .375], respectively). Candida overgrowth among A(-)D(+) patients (40/97, P= .003) was less frequent than among AAD patients, but Candida positivity was not different (80/97, P= .612). In control subjects, Candida positivity and overgrowth were less common than in all other groups. Production of Sap did not differ between patients with AAD and control subjects (P= .568 and P= .590, respectively). Data indicate that elevated Candida counts are a result of antibiotic treatment or diarrhea rather than a cause of AAD.

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Section: Discussioncontrasting

confidence: 99%

“…The role of Candida in antibiotic-associated diarrhea (AAD) has been debated [3][4][5][6]. Fecal concentrations of Candida species of у10 5 cfu/mL stool have been considered to cause diarrhea in patients after antibiotic therapy.…”

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Role of Candida in Antibiotic‐Associated Diarrhea

et al. 2001

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“…Fur thermore, it is known that C. albicans causes acute or chronic superficial infections of mu cous membranes in individuals with normal immune defenses. Interestingly, Kane et al [3] drew attention to the association of bowel disturbances with the presence of large num bers of Candida yeasts in stools. Further more, candidal overgrowth in the gut has already been considered as playing a possible role in the origin of irritable bowel syn drome, and nystatin has been used success fully for its treatment [4,5], In our routine clinical experience, on the other hand, we noted that, on light microscopical examina- tion of fecal samples, yeast-like cells are present virtually in every case; when present in large numbers and in the absence of other known causes of diarrhea, they are invaria bly related to a clinical syndrome character ized by chronic recurrent diarrhea and some times abdominal cramps.…”

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confidence: 99%

Dead Fecal Yeasts and Chronic Diarrhea

Caselli

Trevisani²,

Bighi³

et al. 1988

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The authors report 20 patients in whom a large number of dead or severely damaged yeast cells, supposedly Candida albicans yeasts, were the possible cause of chronic recurrent diarrhea and abdominal cramps. It is suggested that the presence of large numbers of these microorganisms in stools may be considered among the possible etiologies of diarrhea in the ‘irritable bowel syndrome’. The possible source of these yeast-like cells, the causes of cell damage, and the mechanisms by which these organisms may induce diarrhea should be investigated.

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“…A search of the literature revealed only six similarly reported cases. These cases, reported in 1976 by Kane et al [1], described six otherwise healthy people who had at least three months of watery diarrhea and abdominal cramping. All of the cases had stool specimens containing Candida, and all of the patients had resolution of diarrhea following a four-day course of nystatin [1].…”

Section: Discussionmentioning

confidence: 99%