Diarrhea in an infant due to Shigella flexneri 1 carrying multiple cephalosporinase-encoding genes

Albert, M. John; Purohit, Prashant; Poirel, Laurent; Carter, Glen P.; Bulach, Dieter

doi:10.1186/s13099-021-00413-9

Cited by 2 publications

(3 citation statements)

References 47 publications

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“…BlaEC-8 was shown to mediate resistance to cephalosporins including third- (ceftazidime) and fourth-generation (cefepime) cephalosporins [ 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

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Rapid Phenotypic Antibiotic Susceptibility Profiling of Clinical Escherichia coli and Klebsiella pneumoniae Blood Cultures

Hefetz,

Bardenstein,

Rotem

et al. 2024

Antibiotics

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Bloodstream infections (BSI) are defined by the presence of viable bacteria or fungi, accompanied by systemic signs of infection. Choosing empirical therapy based solely on patient risk factors and prior antibiotic susceptibility test (AST) may lead to either ineffective treatment or unnecessarily broad-spectrum antibiotic exposure. In general, Clinical & Laboratory Standards Institute guideline-approved ASTs have a turnaround time of 48–72 h from sample to answer, a period that may result in a critical delay in the appropriate selection of therapy. Therefore, reducing the time required for AST is highly advantageous. We have previously shown that our novel rapid AST method, MAPt (Micro-Agar-PCR-test), accurately identifies susceptibility profiles for spiked bioterrorism agents like Bacillus anthracis, Yersinia pestis and Francisella tularensis directly from whole-blood and blood culture samples, even at low bacterial levels (500 CFU/mL). This study evaluated the performance of MAPt on routine bloodstream infection (BSI), focusing on Escherichia coli and Klebsiella pneumoniae isolates from clinical cultures, including resistant strains to some of the six tested antibiotics. Notably, MAPt yielded results exceeding 95% agreement with the standard hospital method within a significantly shorter timeframe of 6 h. These findings suggest significant potential for MAPt as a rapid and reliable BSI management tool.

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“…BlaEC-8 was shown to mediate resistance to cephalosporins including third- (ceftazidime) and fourth-generation (cefepime) cephalosporins [ 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…BlaEC-8 was shown to mediate resistance to cephalosporins including third-(ceftazidime) and fourth-generation (cefepime) cephalosporins [24,25]. Highlighting the absence of cephalosporin resistance genes in E42 compared to other resistant E. coli isolates.…”

Section: Genome Assembly and Resistance Genes Identification Resultsmentioning

confidence: 99%

Rapid Phenotypic Antibiotic Susceptibility Profiling of Clinical Escherichia coli and Klebsiella pneumoniae Blood Cultures

Hefetz,

Bardenstein,

Rotem

et al. 2024

Antibiotics

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“…El número de episodios de enteritis por patógenos multirresistentes están aumentado en nuestro medio [38]. Los aislamientos de Shigella en muchos países han adquirido rasgos de resistencia que conducen a la ineficacia de las cefalosporinas para el tratamiento de algunos pacientes [40][41][42]. Dentro de este fenómeno de multirresistencia, destaca el grupo de HSH, donde ya se han descrito otras series de shigelosis multirresistente en Australia [43], Francia [44], Reino Unido [45] y España [46].…”

Section: Casounclassified

Shigellosis attended in the emergency department of a regional hospital in southeastern Spain: from their presence to multiresistance

Rodríguez-Guerrero¹,

Herrera-León²,

Gómez-Vicente³

et al. 2023

Rev Esp Quimioter

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Introduction. In the bacterial etiology of severe acute infectious diarrhea, except that caused by Clostridioides difficile, most of them have an invasive character and antibiotic treatment will be necessary in specific situations. Shigella is a classic pathogen, in which it is crucial to know the sensitivity to different classic and alternative antimicrobials. The objective of this work was to analyze the presence of shigellosis and the rate of antibiotic resistance. Methods. A descriptive-retrospective study of the reports of shigellosis of stool cultures issued between January 2016 and April 2022 was conducted. Results. A total of 34 episodes (16 -47.1%- by Shigella sonnei) were observed, as of 2018. There were only 2 pediatric cases. The overall resistance rate to azithromycin, trimethoprim-sulfamethoxazole and ciprofloxacin was 52.9%, 64.7% and 44.1%, respectively. 26.5% were resistant to the 3 groups of antibiotics. There was a higher rate of resistance for S. sonnei. The emergence of resistance to cephalosporins in recent years stands out. Episodes of multidrug-resistant shigellosis were detected between 2020 (1 by S. flexneri) and 2022 (4 by S. sonnei). Conclusions. The episodes of shigellosis are emerging in our environment with a higher rate of multi-resistance. In this context, current empirical treatments for acute enteroinvasive enteritis are at risk of failure, if necessary.

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Diarrhea in an infant due to Shigella flexneri 1 carrying multiple cephalosporinase-encoding genes

Cited by 2 publications

References 47 publications

Rapid Phenotypic Antibiotic Susceptibility Profiling of Clinical Escherichia coli and Klebsiella pneumoniae Blood Cultures

Rapid Phenotypic Antibiotic Susceptibility Profiling of Clinical Escherichia coli and Klebsiella pneumoniae Blood Cultures

Shigellosis attended in the emergency department of a regional hospital in southeastern Spain: from their presence to multiresistance

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