1965
DOI: 10.1016/s0016-5085(65)80143-3
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Diarrhea in Adults Caused by Deficiency in Intestinal Disaccharidases

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Cited by 92 publications
(10 citation statements)
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“…The higher incidence of deficiency of lactase compared with that of the other enzymes is in fair accord with the results of Haemmerli, Kistler, Ammann, Marthaler, and Semenza (1965), Littman and Hammond (1965), and Larrechea, Sampayo, and Miatello (1965), who claimed lactase as the enzyme most susceptible to damage.…”
Section: Discussionsupporting
confidence: 88%
“…The higher incidence of deficiency of lactase compared with that of the other enzymes is in fair accord with the results of Haemmerli, Kistler, Ammann, Marthaler, and Semenza (1965), Littman and Hammond (1965), and Larrechea, Sampayo, and Miatello (1965), who claimed lactase as the enzyme most susceptible to damage.…”
Section: Discussionsupporting
confidence: 88%
“…This condition of lactose intolerance is prevalent in many parts of the world (73) and is primarily caused by deficiency of the enzyme 0-galactosidase in the small intestine (282)(283)(284). Therefore, upon consumption of milk the unhydrolyzed lactose in lactose-intolerant persons passes on to the large intestine where it is acted upon by the indigenous microflora.…”
Section: Enhanced Availability Of Nutrientsmentioning
confidence: 99%
“…As early as the turn of the century, some internists and pediatricians noticed that certain patients were intolerant to sugars or starches, or both, and case reports on "saccharobutyric intestinal putrefaction" or "intestinal carbohydrate dyspepsia" appeared in the literature. 7 Later, when pediatricians spurred the interest of internists concerning diarrhea in infants (predominantly acid feces containing excessive lactic acid) with a concomitant intolerance to milk or milk products, this symptom complex was intensively investigated by Haemmerli and associates. 17 During the past five years specific analytic methods have been developed, and the enzymes in the small intestine have been identified.…”
Section: Disaccharidase Deficiencymentioning
confidence: 99%