Diaporthichalasin, a Novel CYP3A4 Inhibitor from an Endophytic Diaporthe sp.

Pornpakakul, Surachai; Roengsumran, Sophon; Deechangvipart, Suchon; Petsom, Amorn; Muangsin, Nongnuch; Ngamrojnavanich, Nattaya; Sriubolmas, Nongluksna; Chaichit, Narongsak; Ohta, Tomihisa

doi:10.1002/chin.200718197

Cited by 3 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reported production of pycnidione, epolones A and B is limited within the kingdom fungi to only a few species; however, these species belong to considerably different taxonomic orders: the Pleosporales, the Diaporthales, and the Sordariales (Harris et al 1993 ; Pittayakhajonwut et al 2002 ; Pornpakakul et al 2007 ). Pycnidione was first discovered from an isolate that was originally characterized by morphology as an unidentified Phoma species (Harris et al 1993 ) and subsequent sequencing of the D1/D2 region of the nLSU rDNA gene placed this isolate within the Phaeosphaeriaceae (Bills, personal communication 2012).…”

Section: Discussionmentioning

confidence: 99%

Sea foam as a source of fungal inoculum for the isolation of biologically active natural products

et al. 2014

View full text Add to dashboard Cite

Due to a rate increase in the resistance of microbial pathogens to currently used antibiotics, there is a need in society for the discovery of novel antimicrobials. Historically, fungi are a proven source for antimicrobial compounds. The main goals of this study were to investigate the fungal diversity associated with sea foam collected around the coast of Prince Edward Island and the utility of this resource for the production of antimicrobial natural products. Obtained isolates were identified using ITS and nLSU rDNA sequences, fermented on four media, extracted and fractions enriched in secondary metabolites were screened for antimicrobial activity. The majority of the isolates obtained were ascomycetes, consisting of four recognized marine taxa along with other ubiquitous genera and many ‘unknown’ isolates that could not be identified to the species level using rDNA gene sequences. Secondary metabolite isolation efforts lead to the purification of the metabolites epolones A and B, pycnidione and coniothyrione from a strain of Neosetophoma samarorum; brefeldin A, leptosin J and the metabolite TMC-264 from an unknown fungus (probably representative of an Edenia sp.); and 1-hydroxy-6-methyl-8-hydroxymethylxanthone, chrysophanol and chrysophanol bianthrone from a Phaeospheria spartinae isolate. The biological activity of each of these metabolites was assessed against a panel of microbial pathogens as well as several cell lines.

show abstract

Section: Discussionmentioning

confidence: 99%

Sea foam as a source of fungal inoculum for the isolation of biologically active natural products

et al. 2014

View full text Add to dashboard Cite

show abstract

“…have been subjected to intense chemical investigation by several research groups and various new secondary metabolites have been described in the last decade, including polyketides, terpenes, and compounds of mixed origin such as cytochalasins (e.g. Wagenaar & Clardy 2001;Weber et al 2004;Dai et al 2005a, b;Pornpakakul et al 2007). Novel secondary metabolites were also described from related Diaporthales, such as Cytospora species (Brady et al 2000;He et al 2003).…”

Section: Introductionmentioning

confidence: 98%

Chemical and molecular characterization of Phomopsis and Cytospora-like endophytes from different host plants in Brazil

Abreu¹,

Costa²,

Pfenning³

et al. 2012

Fungal Biology

View full text Add to dashboard Cite

“…As dominant endophytes, Phomopsis spp. have been subjected to intense chemical investigation and various new secondary metabolites have been described, including polyketides, terpenes, and compounds of mixed origin, such as cytochalasins [ 9 , 10 , 11 , 12 , 13 , 14 ]. We report in this paper the identification of bioactive metabolites produced by an endophytic Phomopsis sp.…”

Section: Introductionmentioning

confidence: 99%

Metabolites Produced by an Endophytic Phomopsis sp. and Their Anti-TMV Activity

Tan

Fang

et al. 2017

Molecules

View full text Add to dashboard Cite

The fermentation and isolation of metabolites produced by an endophytic fungus, which was identified as Phomopsis sp. FJBR-11, based on phylogenetic analysis, led to the identification of six compounds, including dothiorelones A–C, and H, and cytosporones C and U. Among these compounds, cytosporone U exhibited potent inhibitory activity against Tobacco mosaic virus (TMV). Moreover, the crude and a purified exopolysaccharide were proved to possess strong inhibitory effects against the virus infection.

show abstract

Diaporthichalasin, a Novel CYP3A4 Inhibitor from an Endophytic Diaporthe sp.

Cited by 3 publications

References 1 publication

Sea foam as a source of fungal inoculum for the isolation of biologically active natural products

Sea foam as a source of fungal inoculum for the isolation of biologically active natural products

Chemical and molecular characterization of Phomopsis and Cytospora-like endophytes from different host plants in Brazil

Metabolites Produced by an Endophytic Phomopsis sp. and Their Anti-TMV Activity

Contact Info

Product

Resources

About