Diaphragmatic paralysis: Evaluation in infants with congenital Zika syndrome

Linden, Vanessa van der; Lins, Otávio Gomes; Petribu, Natacha Calheiros de Lima; Melo, Ana Cláudia Marques Gouveia de; Moore, Jazmyn; Rasmussen, Sonja A.; Moore, Cynthia A.

doi:10.1002/bdr2.1597

Cited by 11 publications

(8 citation statements)

References 39 publications

(37 reference statements)

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“…All the papers that evaluated the central nervous system found neurological alterations, and the main ones were seizure, epilepsy, irritability, pyramidal syndrome, sleep disorders, and hyperexcitability ( 5 , 12 , 18 , 19 , 27 , 31 , 35 , 36 , 42 , 45 , 46 , 48 , 50 , 51 , 54 , 56 , 61 , 62 , 66 , 69 – 71 , 74 , 77 ). Regarding neuro-psychomotor development, all 15 papers reported motor, cognitive, or language delay ( 10 , 11 , 15 , 17 , 18 , 24 , 32 , 33 , 44 , 47 , 52 , 58 , 61 , 62 , 65 ).…”

Section: Resultsmentioning

confidence: 99%

“…Regarding genitourinary characteristics, studies reported neurogenic bladder and cryptorchidism ( 22 , 23 , 72 ). The most common orthopedic alteration was arthrogryposis ( 12 , 16 , 21 , 36 , 42 , 46 , 57 ). All papers that evaluated gastrointestinal manifestations reported dysphagia ( 38 , 46 , 48 , 61 ).…”

Section: Resultsmentioning

confidence: 99%

“…19,27,31,35,36,42,45,46,48,50,51,FIGURE 2 | Zika studies reviewed by year of publication and country of origin. 54, 56, 61, 62, 66, 69-71, 74, 77).…”

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confidence: 99%

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Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review

Amaral¹,

Malacarne²,

Brandão³

et al. 2021

Front. Psychiatry

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Background: Vertical transmission of Zika Virus (ZIKV) can be associated with several clinical features in newborn infants. The goal of the present review was to analyze the current state of knowledge regarding clinical repercussions following perinatal exposure to ZIKV in children up to 3 years of age.Methods: A systematic review of published studies was carried out, without the restriction of language or date of publication, identified in the databases PubMed, Virtual Health Library (BVS), Scopus, and Web of Science and the catalog for CAPES theses and dissertations. According to the proposed flowchart, the bibliographic search resulted in 1,563 papers. Of these, according to the eligibility criteria, 70 were selected for systematic review; all were published between 2016 and 2021.Results: Regarding clinical findings, 19 papers evaluated clinical imaging alterations, 21 ophthalmic manifestations, and 39 evaluated the central nervous system; of these, 15 analyzed neuro-psychomotor development. The remainder evaluated audiological (n = 14), nutritional (n = 14), orthopedic (n = 7), cardiorespiratory (n = 5), genitourinary (n = 3) or endocrinological (n = 1) manifestations.Conclusion: It is critical for studies to continue monitoring children with antenatal ZIKV exposure as they grow, given the unknown long-term repercussions of ZIKV and the recognized postnatal complications of this infection during pregnancy. Broader descriptions of observed clinical findings are also important in order to characterize the entire spectrum of disease in children.Systematic Review Registration: PROSPERO REGISTER: CRD42020205947.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review

Amaral¹,

Malacarne²,

Brandão³

et al. 2021

Front. Psychiatry

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“…Brainstem cranial nerves are often affected, leading to oromotor dysfunction, persistent swallowing disorders and respiratory problems ( Pereira et al, 2020 ). Diaphragmatic paralysis due to the phrenic nerve dysfunction was reported in 3 of 120 (3.6%) infants with CZS with the need for assisted ventilation, and led to early death ( van der Linden et al, 2019a ).…”

Section: Congenital Zika Syndromementioning

confidence: 99%

Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

et al. 2022

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Five years after the identification of Zika virus as a human teratogen, we reviewed the early clinical manifestations, collectively called congenital Zika syndrome (CZS). Children with CZS have a very poor prognosis with extremely low performance in motor, cognitive, and language development domains, and practically all feature severe forms of cerebral palsy. However, these manifestations are the tip of the iceberg, with some children presenting milder forms of deficits. Additionally, neurodevelopment can be in the normal range in the majority of the non-microcephalic children born without brain or eye abnormalities. Vertical transmission and the resulting disruption in development of the brain are much less frequent when maternal infection occurs in the second half of the pregnancy. Experimental studies have alerted to the possibility of other behavioral outcomes both in prenatally infected children and in postnatal and adult infections. Cofactors play a vital role in the development of CZS and involve genetic, environmental, nutritional, and social determinants leading to the asymmetric distribution of cases. Some of these social variables also limit access to multidisciplinary professional treatment.

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“…van der Linden et al, 2016). Another defect more recently identified as associated with congenital Zika virus infection is diaphragmatic paralysis due to phrenic nerve palsy (Rajapakse et al, 2018;V. van der Linden et al, 2019).…”

Section: Zika Virus and Birth Defectsmentioning

confidence: 99%

Teratogen update: Zika virus and pregnancy

Rasmussen

Jamieson

2020

Birth Defects Research

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Zika virus was first identified in Uganda in 1947 but received little attention until 2015 when a large outbreak of Zika virus illness followed by an increased number of babies born with microcephaly occurred in Brazil. Zika virus spread rapidly throughout the Americas, and in 2016 was identified as a cause of microcephaly and other serious birth defects. Since that time, much has been learned about the Zika virus. The virus is primarily spread by the bite of Aedes species mosquitoes; however, other forms of transmission (e.g., sexual and intrauterine) have been recognized. Although postnatal Zika virus infection typically causes mild or no symptoms, effects on infants born to prenatally infected mothers can be severe and include structural birth defects and neurodevelopmental effects. The risk of a structural birth defect among infants born to mothers with confirmed or suspected Zika virus infection during pregnancy has ranged from 5 to 10%. The timing of Zika infection during pregnancy affects risk, with higher risks with the first‐trimester infection. Neurodevelopmental effects are seen even in infants who appear normal in the newborn period. Although cases of Zika virus infection have fallen in the Americas, the Zika virus remains an active threat in some regions of the world. The development of a Zika vaccine will require continued focus and investment. Until a Zika vaccine is available, prevention efforts for pregnant women include avoidance of travel to areas with active Zika transmission, avoidance of mosquito bites for those living in or traveling to areas with Zika transmission, and protection against sexual transmission.

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Diaphragmatic paralysis: Evaluation in infants with congenital Zika syndrome

Cited by 11 publications

References 39 publications

Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review

Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review

Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

Teratogen update: Zika virus and pregnancy

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