Abstract:Introduction: Diaphragm function may be impaired in children with sickle cell disease (SCD). We hypothesized that diaphragm function is related to performance and ventilation on the 6-min walk test (6MWT).Methods: Respiratory muscle testing, diaphragm ultrasonography, and the 6MWT with portable gas analysis were performed on children with SCD and age-and sex-matched controls.Results: Fourteen children with SCD were enrolled. Comparisons were made between nine children with SCD (9.89 ± 2.93 years) and nine cont… Show more
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