Diaphragm Disease of the Small Intestine

Ullah, Sana; Ajab, Shereen; Rao, Rajashekhar; Raghunathan, Girish; DaCosta, P

doi:10.1177/1066896914563392

Cited by 8 publications

(6 citation statements)

References 8 publications

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“…This made surgery mandatory, as florid locoregional lymphadenopathy has not been previously described in diaphragm disease 6 11. There has been one previous report of diaphragm disease being misdiagnosed with malignancy, however, in this patient there was ongoing treatment for malignancy and imaging showed only minor mesenteric lymph node enlargement 12. The diagnosis of diaphragm disease largely rests on a history of NSAIDs use, anaemia, symptoms of small bowel obstruction and the finding of small bowel strictures on imaging.…”

Section: Discussionmentioning

confidence: 87%

Small bowel diaphragm disease mimicking malignancy

et al. 2015

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Non-steroidal anti-inflammatory drugs (NSAIDs) can produce diaphragm disease where multiple strictures develop in the small bowel. This typically presents with anaemia and symptoms of small bowel obstruction. The strictures develop as a result of circumferential mucosal ulceration with subsequent contraction of rings of scar tissue. We report a case of a 47-year-old woman with a 6-month history of NSAIDs abuse who presented with subacute small bowel obstruction 1 year after stopping NSAIDs. CT and MRI showed multiple ileal strictures with florid locoregional lymphadenopathy. A malignant diagnosis such as lymphoma was considered likely as florid mesenteric lymphadenopathy has not been previously reported in diaphragm disease. Laparotomy with small bowel resection was therefore performed. Histology showed diaphragm disease with the enlarged mesenteric nodes having reactive features. Gross locoregional lymphadenopathy should not deter a diagnosis of diaphragm disease in cases of multiple small bowel strictures where there is a strong history of NSAIDs use.

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Section: Discussionmentioning

confidence: 87%

Small bowel diaphragm disease mimicking malignancy

et al. 2015

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“…These rings differ from the membranes by their greater thickness. The clinical features can be iron deficiency anemia, intestinal obstruction, a change in bowel habits or acute abdomen secondary to perforation (1,2). It is usually associated with a sustained use of high doses of non-steroidal anti-inflammatory drugs (1-3), but this patient denied any use of these drugs.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis is sometimes difficult due to the fact that the usual imaging tests do not detect the alterations produced by this disease (1,3). It usually requires the use of a capsule endoscopy or enteroscopy with biopsies (1,3). The differential diagnosis is broad, such as infections, lymphoma and systemic diseases, among others.…”

Section: Discussionmentioning

confidence: 99%

Enteroscopic diagnosis of intestinal malabsorption of a rare etiology: diaphragm disease

Alcázar¹,

Maldonado²,

Colomo³

et al. 2020

Rev Esp Enferm Dig

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“…Therapy with long-term nonsteroidal anti-inflammatory drugs (NSAIDs) may play a role in the development of small bowel alterations (4). Malignant tumours of the small bowel include adenocarcinoma, carcinoid, lymphoma, leiomyosarcoma, and GIST (5).…”

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confidence: 99%

Recurrent Leiomyosarcoma of the Small Bowel: A Case Series

et al. 2020

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Background/Aim: Leiomyosarcoma is an extremely rare, small bowel neoplasm (2% of all gastrointestinal tumours). Early diagnosis is challenging due to the slow growth of the cancer. The biological behaviour of this group of tumours is aggressive, and the first-line treatment is surgical resection. Patients and Methods: This is a report of 4 cases of small bowel leiomyosarcoma that were treated in the last ten years at Hospital San Martino: one involving the jejunum and three involving the ileum (age range=69-86 years). Three patients underwent surgical resection and one was treated with chemotherapy. Results: All patients who were eligible for surgery underwent radical resection with R0 margins. Mean overall survival was 33 months (range=8-84 months). Conclusion: Specific guidelines for small bowel leiomyosarcoma do not currently exist and these rare cases should be discussed in a multidisciplinary context. The first treatment approach is surgery, and in some cases, multivisceral resection may be needed to obtain free margins, even in recurrent cases.

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Diaphragm Disease of the Small Intestine

Cited by 8 publications

References 8 publications

Small bowel diaphragm disease mimicking malignancy

Small bowel diaphragm disease mimicking malignancy

Enteroscopic diagnosis of intestinal malabsorption of a rare etiology: diaphragm disease

Recurrent Leiomyosarcoma of the Small Bowel: A Case Series

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