Diaper Dermatitis

Helms, Lauren; Burrows, Heather L.

doi:10.1542/pir.2020-0128

Cited by 5 publications

(11 citation statements)

References 3 publications

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“…It is claimed that with this, secondary infections are prevented and the hydrophobic structure of the fatty acids in the HM structure prevents the damage that may occur from feces and urine. 8 , 17 , 19 , 20 …”

Section: Resultsmentioning

confidence: 99%

The Use of Human Milk for Therapeutic Purposes Other Than Nutrition

Demirtaş¹,

Yalçin²

2022

Turk Arch Pediatrics

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Human milk is a popular treatment method applied as a traditional, natural pharmacotherapy that has been going on for many years in many societies. Due to its low cost, widespread and easy use, and lack of undesirable effects, breast milk also has the potential to play a role in evidence-based treatment for tertiary people as well as infant and maternal health. Scientific databases were searched for Literature search from January 1995 to December 2021, including Ovid, PubMed, Google Scholar, Science Direct, ResearchGate, Web of Science Core Collection (Clavirate), and a total of 45 articles from 142 articles written in English were included in the study. According to the results of the current studies reviewed, there is a general conclusion about the positive effects of human milk in the treatment of tertiary persons in addition to the prevention and treatment of common maternal and infantile diseases. Human milk can be used as a different alternative in further studies, especially based on anti-tumoral and cancer studies. In addition, an accessible, safe, and suitable alternative treatment for the treatment of allergic skin and mucous tissue damage in infants and mothers may be suitable for societies with limited access to treatment.

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Section: Resultsmentioning

confidence: 99%

The Use of Human Milk for Therapeutic Purposes Other Than Nutrition

Demirtaş¹,

Yalçin²

2022

Turk Arch Pediatrics

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“…Metabolism of HMOs by B. infantis results in the formation of organic acids, mainly lactic and acetic acids, which lowers the fecal pH. The acidified gut milieu is both deterrent to the proliferation of detrimental bacteria including known pathogens ( 4 , 5 ) as well as a deactivator for fecal enzymes implicated in the breakdown of skin, leading to diaper dermatitis ( 52 ). Therefore, the results generated from this study and from previous studies utilizing EVC001 support that this strain provides infants with the capacity to metabolize HMOs with positive results in immune development, as well as decreasing the risk of developing co-morbidities common to prematurity and related to enteric inflammatory conditions, such as NEC ( 51 ).…”

Section: Discussionmentioning

confidence: 99%

B. infantis EVC001 Is Well-Tolerated and Improves Human Milk Oligosaccharide Utilization in Preterm Infants in the Neonatal Intensive Care Unit

et al. 2022

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Not all infants carry specialized gut microbes, meaning they cannot digest human milk oligosaccharides and therefore do not receive complete benefits from human milk. B. infantis EVC001 is equipped to convert the full array of complex oligosaccharides into compounds usable by the infant, making it an ideal candidate to stabilize gut function and improve nutrition in preterm infants. A prospective, open-label study design was used to evaluate the tolerability of B. infantis EVC001 and its effects on the fecal microbiota in preterm infants in a Neonatal Intensive Care Unit. Thirty preterm infants <1,500 g and/or <33 weeks gestation at birth were divided into two matched groups, and control infants were enrolled and discharged prior to enrolling EVC001 infants to prevent cross-colonization of B. infantis: (1) fifteen control infants received no EVC001, and (2) fifteen infants received once-daily feedings of B. infantis EVC001 (8.0 x 109 CFU) in MCT oil. Clinical information regarding medications, growth, nutrition, gastrointestinal events, diagnoses, and procedures was collected throughout admission. Infant stool samples were collected at baseline, Study Days 14 and 28, and 34-, 36-, and 38-weeks of gestation. Taxonomic composition of the fecal microbiota, functional microbiota analysis, B. infantis, and human milk oligosaccharides (HMOs) in the stool were determined or quantified using 16S rRNA gene sequencing, metagenomic sequencing, qPCR, and mass spectrometry, respectively. No adverse events or tolerability issues related to EVC001 were reported. Control infants had no detectable levels of B. infantis. EVC001 infants achieved high levels of B. infantis (mean = 9.7 Log10 CFU/μg fecal DNA) by Study Day 14, correlating with less fecal HMOs (ρ = −0.83, P < 0.0001), indicating better HMO utilization in the gut. In this study, B. infantis EVC001 was shown to be safe, well-tolerated, and efficient in colonizing the preterm infant gut and able to increase the abundance of bifidobacteria capable of metabolizing HMOs, resulting in significantly improved utilization of human milk.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT03939546, identifier: NCT03939546.

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Section: Impact Of Using Diapers In Preterm Infantsmentioning

confidence: 99%

“…20 The increased incidence of diaper dermatitis in the NICU is largely due to these variations across body locations (21-45.4%). 21 As a result, even if less stressful to the newborn, implementing potential stress-reduction treatments such as reducing the frequency of diaper changes could worsen diaper dermatitis and hence, influence infant health. 21 The summary of literature comparing the impact of diaper procedures in neurodevelopment, musculoskeletal, and skin aspects in premature infants is listed in Table 1 .…”

Section: Musculoskeletal Aspectsmentioning

confidence: 99%

“…21 As a result, even if less stressful to the newborn, implementing potential stress-reduction treatments such as reducing the frequency of diaper changes could worsen diaper dermatitis and hence, influence infant health. 21 The summary of literature comparing the impact of diaper procedures in neurodevelopment, musculoskeletal, and skin aspects in premature infants is listed in Table 1 .…”

Section: Musculoskeletal Aspectsmentioning

confidence: 99%

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Diaper Use in Preterm Neonates: Effects on Skin, Musculoskeletal System, and Neurodevelopment

Corebima

Sulistijono

Akmaly

et al. 2022

Journal of Neonatology

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Caring for preterm infants in the intensive care unit can lead to a variety of conditions that increase stress and pain during routine care procedures. One of the intensive care unit procedures is diapers usage and change. The immature anatomical and physiological growth and development, especially the musculoskeletal system, neurological system, and integumentary system, is a challenge in the care of premature infants. Inappropriate diapers in premature infants can result in neurodevelopment problems, diaper dermatitis, and long-term postural disorders. Supportive care in the intensive care unit should include maintaining sleep cycles, creating a comfortable environment, periodic stress and pain measurement, practicing infants’ skincare, and care involving parents.

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Diaper Dermatitis

Cited by 5 publications

References 3 publications

The Use of Human Milk for Therapeutic Purposes Other Than Nutrition

The Use of Human Milk for Therapeutic Purposes Other Than Nutrition

B. infantis EVC001 Is Well-Tolerated and Improves Human Milk Oligosaccharide Utilization in Preterm Infants in the Neonatal Intensive Care Unit

Diaper Use in Preterm Neonates: Effects on Skin, Musculoskeletal System, and Neurodevelopment

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