Diamond Nanothermometry

Sotoma, Shingo; Epperla, Chandra Prakash; Chang, Huan‐Cheng

doi:10.1002/cnma.201700257

Cited by 54 publications

(68 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Temperature is one of the basic variables in science and with the latest advancements in nanothermometry nowadays it can be measured with submicrometric spatial resolution [1].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles-based magnetic and photo induced hyperthermia for cancer treatment

et al. 2019

View full text Add to dashboard Cite

2.3.3. Multifunctional hybrid systems 2.3.4. High magnetic moment core@shell nanoparticles 2.4. Instrumentation for magnetic-induced hyperthermia 3. Photo-induced hyperthermia 3.1. Mechanisms of Photo-induced hyperthermia 3.1.1. Surface plasmon resonance absorption 3.1.2. Interactions between light and carbon reticle vibrational state 3.1.3. Generation of heat in nanoparticles: role of non-radiative recombination 3.2. Parameters affecting the photo-induced hyperthermia 3.3. Potential photo-induced hyperthermia nanomaterial 3.3.1. Carbon Nanostructures 3.3.2. Au nanomaterials 3.3.3. Iron oxide nanoparticles (IONPs) and Ferrites 3.3.4. Quantum Dots (QDs) 3.3.5. Rare-earth containing NPs 3.4. Instrumentation for photo-induced hyperthermia 4. Comparison between magnetic and photo-induced hyperthermia and their combinatorial effect 5. Prerequisites for hyperthermia treatment in the clinic 5.1. Parameter affecting toxicity: size, shape, composition, coating 5.2. Biodistribution, pharmacokinetics and clearance rate 5.3. Concentration required for treatment 5.4. Drug release by external thermal therapy 5.5. In vivo and clinical application of hyperthermia treatments 5.5.1. Tumor microenviroment and hyperthermia effects 5.5.2. Delivery routes of nanoparticles in tumors 5.5.3.Examples of in vivo and clinical application of hyperthermia treatment 6. Conclusion and future perspectives Conflict of interest:

show abstract

“…Temperature is one of the basic variables in science and with the latest advancements in nanothermometry nowadays it can be measured with submicrometric spatial resolution [1].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles-based magnetic and photo induced hyperthermia for cancer treatment

et al. 2019

View full text Add to dashboard Cite

show abstract

“…FNDs containing negatively charged nitrogen vacancy centers (NVCs) are known as a fluorescent nanomaterial with exceptional photostability, showing neither photobleaching nor photoblinking 28,29 . In addition, their unique magneto-optical properties allow nanoscale temperature measurement through optically detected magnetic resonance (ODMR) technique with accuracy better than 1 K 30,31 . Since NVCs are deeply embedded inside a diamond crystal with high thermal conductivity (larger than 50 Wm -1 K -1 ) 32 , its thermosensing ability is little influenced by environmental factors 33 .…”

Section: Introductionmentioning

confidence: 99%

In situ measurement of intracellular thermal conductivity using heater-thermometer hybrid diamond nanosensor

Sotoma

Zhong

Kah

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Understanding heat dissipation processes at nanoscale during cellular thermogenesis is essential to clarify the relationships between the heat and biological processes in cells and organisms. A key parameter determining the heat flux inside a cell is the local thermal conductivity, a factor poorly investigated both experimentally and theoretically. Here, using a nanoheater/nanothermometer hybrid based on a polydopamine shell encapsulating a fluorescent diamond nanocrystal, we measured the intracellular thermal conductivity of HeLa cell with a spatial resolution of about 200 nm. Its mean value of 0.11 Wm -1 K -1 determined for the first time is significantly smaller than that of water. Bayesian analysis of the data strongly supports the existence of variation of the intracellular thermal conductivity of about 40%. These results present a major milestone towards understanding the intracellular heat transfer phenomena at nanoscale.

show abstract

“…Fluorescent nanodiamonds (FNDs) containing negatively-charged nitrogen-vacancy centers (NV − s) have recently been reported as a novel class of thermometers [ 12 , 13 ]. In Figure 1a , the energy level diagram of NV − is displayed.…”

mentioning

confidence: 99%

Fluorescent nanodiamonds as a robust temperature sensor inside a single cell

2018

Self Cite

View full text Add to dashboard Cite

Thermometers play an important role to study the biological significance of temperature. Fluorescent nanodiamonds (FNDs) with negatively-charged nitrogen-vacancy centers, a novel type of fluorescence-based temperature sensor, have physicochemical inertness, low cytotoxicity, extremely stable fluorescence, and unique magneto-optical properties that allow us to measure the temperature at the nanoscale level inside single cells. Here, we demonstrate that the thermosensing ability of FNDs is hardly influenced by environmental factors, such as pH, ion concentration, viscosity, molecular interaction, and organic solvent. This robustness renders FNDs reliable thermometers even under complex biological cellular environment. Moreover, the simple protocol developed here for measuring the absolute temperature inside a single cell using a single FND enables successful temperature measurement in a cell with an accuracy better than ±1°C.

show abstract

Diamond Nanothermometry

Cited by 54 publications

References 67 publications

Nanoparticles-based magnetic and photo induced hyperthermia for cancer treatment

Nanoparticles-based magnetic and photo induced hyperthermia for cancer treatment

In situ measurement of intracellular thermal conductivity using heater-thermometer hybrid diamond nanosensor

Fluorescent nanodiamonds as a robust temperature sensor inside a single cell

Contact Info

Product

Resources

About