Diamine oxidase in diagnosis of acute mesenteric ıschemia

Karabulut, Keziban Uçar; Narcı, Hüseyin; Gül, Mehmet; Dündar, Zerrin Defne; Cander, Başar; Girişgin, Abdullah Sadık; Erdem, Sami

doi:10.1016/j.ajem.2012.07.029

Cited by 13 publications

(12 citation statements)

References 17 publications

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“…Recent evidence suggests that the rise in plasma DAO level is strongly associated with the severity of intestinal tissue damage [35]. Therefore, the activity of plasma DAO can manifest the intestinal status and will increase in case of intestinal ischemia [34]. In our study, with a smaller increase of levels of Cr, BUN, IFABP and DAO, potential renal and intestinal protection by CRRT cooling was proved.…”

Section: Discussionsupporting

confidence: 62%

“…Evidence has shown a linear relation between max endotoxin level and max IFABP (p = 0.01), suggesting that the higher the intestinal injury, the higher the level of endotoxin [9]. And DAO is an intracellular enzyme mainly located in intestinal mucosa, catalyzing oxidative deamination of diamines [34]. Recent evidence suggests that the rise in plasma DAO level is strongly associated with the severity of intestinal tissue damage [35].…”

Section: Discussionmentioning

confidence: 99%

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Fast Hypothermia Induced by Continuous Renal Replacement Therapy Alleviates Renal and Intestinal Injury after Cardiac Arrest in Swine

Shi

Wang³

et al. 2020

Preprint

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Background: Renal and intestinal damage lead to multiple organ dysfunction and death after cardiopulmonary resuscitation (CPR), and can be partly mitigated by therapeutic hypothermia. Currently, continuous renal replacement therapy (CRRT) was demonstrated to be an effective way to induce hypothermia. In the present study, we aimed to investigate the influence of CRRT cooling on renal and intestinal damage after CPR based on a porcine model.Methods: 32 swine were subjected to ventricular fibrillation for 8 min, while defibrillation was performed at 5 min of CPR. All pigs were randomly allocated to receive CRRT (n = 9), surface cooling (SC, n = 9), normothermia (NT, n = 9) or sham control (Control, n = 5) at 5 min post resuscitation. In the CRRT group, the pigs were cooled by the combination of 8-hr CRRT and 16-hr SC, a rate of 180 ml/min of blood flow was initially set with the infusion line submerged in 4 °C of ice water. In the SC group, pigs were cooled by the 24-hr SC. As to the NT and Control groups, the temperatures were maintained at a normal range. The levels of creatinine (Cr), blood urea nitrogen (BUN), intestinal fatty acid binding protein (IFABP) and diamine oxidase (DAO) in serum were measured at baseline and at 1, 3, 6, 12, 24 and 30h post resuscitation. Additionally, tissues of kidney and intestine were harvested, from which the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), the contents of malondialdehyde (MDA), activities of superoxide dismutase (SOD) and the apoptosis levels were analyzed. Results: After resuscitation, the blood temperature decreased significantly more rapidly in the CRRT group than in the SC group (9.8 ± 1.6 vs. 1.5 ± 0.4 ℃/h, P < 0.01). The levels of Cr, BUN, IFABP and DAO after resuscitation were significantly lower in the two hypothermic groups compared with the NT group. Furthermore, from pathological evidence, cooling induced by CRRT alleviated post-resuscitation renal and intestinal injury compared to SC.Conclusion: Fast hypothermia induced by continuous renal replacement therapy was superior to surface cooling in mitigating renal and intestinal injury post resuscitation.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Fast Hypothermia Induced by Continuous Renal Replacement Therapy Alleviates Renal and Intestinal Injury after Cardiac Arrest in Swine

Shi

Wang³

et al. 2020

Preprint

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“…Karabulut et al провели сравнение уровней альфа-амилазы и диами-нооксидазы в крови при экспериментальной перевязке верхней мезентериальной артерии у кроликов. Авторы отметили повышение уровня амилазы и снижение диаминоксидазы начиная с 1 часа [32]. В экспериментальном исследо-вании на кроликах, выполненном F.X.…”

Section: биохимические маркеры острой интестинальной ишемииunclassified

New Biomarkers of Acute Mesenteric Ischemia

Чернооков¹,

Bozhedomov²,

Atayan³

et al. 2018

Novosti Khirurgii

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СОВРЕМЕННЫЕ БИОМАРКЕРЫ ОСТРОЙ ИНТЕСТИНАЛЬНОЙ ИШЕМИИПервыйОстрая интестинальная ишемия является одной из наиболее сложных проблем в ургентной хирургии в силу высокой летальности, одной из причин которой является поздняя диагностика. Оперативное лече-ние часто проводится в фазу разлитого перитонита.С целью выделения наиболее доступных и точных способов ранней диагностики острой интести-нальной ишемии выполнен данный обзор литературы.В настоящее время для диагностики острой интестинальной ишемии используют немногочислен-ный ряд биомаркеров, таких как α-глутамат-S-трансфераза, D-димеры, прокальцитонин, D-лактат, кишеч-ный белок, связывающий жирные кислоты (I-FABP), ишемия-модифицированный альбумин. По данным литературы, наиболее высокие показатели чувствительности и специфичности выявлены у I-FABP (75-85% и 70-80% соответственно), α-глутамат-S-трансферазы (67,8% и 84,2%), ишемия-модифицированного альбумина (94,7% и 86,4%). Кроме этого, для ранней диагностики в настоящее время используются до-рогостоящие и инвазивные методы, такие как КТ-ангиография, МРТ с контрастированием, селективная ангиография, однако данные технологии доступны не всем лечебным учреждениям.Для решения проблемы улучшения ранней диагностики острой интестинальной ишемии следует про-водить дальнейший поиск различных биомаркеров и их более широкое внедрение в клиническую практику. Ключевые слова: острая интестинальная ишемия, биомаркеры, диагностика, мезентериальный тромбоз, кишечный белок, связывающий жирные кислоты (I-FABP)The acute mesenteric ischemia is one of the most complex problems in the urgent surgery because of the high mortality, the cause of which is late diagnosis. The operation treatment is often provided in the phase of diffuse peritonitis.This literature review is done in order to identify the most accessible and accurate methods of early diagnosis of the acute mesenteric ischemia.At present time rather a small number of biomarkers for diagnosing the acute mesenteric ischemia are used, such as α-glutamate-S-transferase, D-dimers, procalcitonin, D-lactate, intestinal fatty acid binding protein (I-FABP), ischemia-modified albumin. According to the literature the highest sensitivity and specificity were found in I-FABP (75-85% and 70-80% respectively), α-glutamate-S-transferase (67.8% and 84.2%), ischemia-modified albumin (94.7% and 86.4%). In addition, expensive and invasive methods are currently used for early diagnosis, such as CT angiography, contrast-enhanced MRI, selective angiography. However, these technologies are not available to all medical institutions.We should continue further search of various biomarkers and their more widespread introduction to clinical practice in order to solve the problem of early acute mesenteric ischemia diagnostics.

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“…reported that DAO activity in the blood significantly correlates with DAO activity in the tissues of the small intestine in animals . Several studies have been reported in which DAO activity was measured and small intestinal lesions were assessed in patients with inflammatory bowel disease, acute mesenteric ischemia, and other diseases . However, there have been only a few reports on the relationship between DAO activity and anticancer‐drug‐induced mucosal damage .…”

Section: Introductionmentioning

confidence: 99%

“…11 Several studies have been reported in which DAO activity was measured and small intestinal lesions were assessed in patients with inflammatory bowel disease, acute mesenteric ischemia, and other diseases. [12][13][14][15][16] However, there have been only a few reports on the relationship between DAO activity and anticancer-drug-induced mucosal damage. [17][18][19] Moriyama et al measured serum DAO activity in rats, comparing gastrointestinal damage between the group receiving S-1 containing potassium oxonate (Oxo) (which reduces gastrointestinal damage) and the group receiving S-1 without Oxo.…”

Section: Introductionmentioning

confidence: 99%