Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial

Izquierdo-Casas, Joan; Comas-Basté, Oriol; Latorre‐Moratalla, M. Luz; Lorente-Gascón, Marian; Duelo, Adriana; Soler-Singla, L; Vidal‐Carou, M. Carmen

doi:10.1016/j.clnu.2018.01.013

Cited by 48 publications

(45 citation statements)

References 29 publications

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“…However, these drugs have several side effects [7]. Hence, several supplementary treatments have been suggested for the management of migraine symptoms [8][9][10][11]. Among these methods, supplementation with some micronutrients receives a great deal of attention [2,9,12,13].…”

Section: Introductionmentioning

confidence: 99%

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial

Ahmadi

Mazloumi-Kiapey

Sadeghi

et al. 2020

Nutr J

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Background Observational studies have shown a link between zinc deficiency and migraine headaches. We aimed to examine the effect of zinc supplementation on the characteristics of migraine attacks in patients with migraine. Methods This randomized clinical trial was conducted on 80 patients with migraine. Patients were randomly assigned to receive either zinc sulfate (220 mg/d zinc sulfate) or placebo (lactose) for 8 weeks. Anthropometric measures, serum zinc concentrations, and characteristics of migraine attacks (headache severity, frequency and duration of migraine attacks, and headache daily results) were assessed at baseline and end of the trial. Results Compared with the placebo, zinc supplementation resulted in a significant reduction in headache severity (− 1.75 ± 1.79 vs. -0.80 ± 1.57; P = 0.01) and migraine attacks frequency (− 2.55 ± 4.32 vs. -0.42 ± 4.24; P = 0.02) in migraine patients. However, the observed reduction for headache severity became statistically non-significant when the analysis was adjusted for potential confounders and baseline values of headache severity. Other characteristics of migraine attacks including the duration of attacks and headache daily results were not altered following zinc supplementation either before or after controlling for covariates. Conclusion Zinc supplementation had a beneficial effect on the frequency of migraine attacks in migraine patients. Additional well-designed clinical trials with a long period of intervention and different dosages of zinc are required. Trial registration code IRCT20121216011763N23 at www.irct.ir.

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Section: Introductionmentioning

confidence: 99%

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial

Ahmadi

Mazloumi-Kiapey

Sadeghi

et al. 2020

Nutr J

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“…The supplementation of exogenous porcine DAO to support the endogenous DAO in the human intestine is claimed to reduce histamine‐associated physiological symptoms (Izquierdo‐Casas et al., 2019; Komericki et al., 2011; Schnedl et al., 2019; Yacoub et al., 2018). However, we showed in our histamine reduction experiments that the DAO activity required for a satisfactory supplementation is considerably higher than expected.…”

Section: Resultsmentioning

confidence: 99%

“…In the study by Yacoub et al (2018), DAO supplementation was found to be effective in relieving symptoms of urticaria. Recently, the studies by Izquierdo-Casas et al (2019) and Schnedl et al (2019) stated that the supplementation with DAO reduced the duration of migraine attacks and histamine intolerance related symptoms in general, respectively. This is not in accordance with our in vitro results and theoretical conclusions thereof.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of porcine diamine oxidase for the conversion of histamine in food‐relevant amounts

Kettner

Seitl

Fischer

2020

Journal of Food Science

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Histamine exists in a multitude of foods and displays an emerging role within food intolerances. Our aim was to identify the activity of porcine diamine oxidase (DAO) required for the in vitro degradation of histamine amounts that are found in typical meals containing histamine (75 mg, equaled 150 mg/L). Furthermore, we investigated an actual dietary supplement that is commercially available for histamine intolerant individuals for its histamine reduction capability. Kinetic investigations of porcine DAO showed a substrate inhibition by histamine concentrations greater than 56 mg/L (0.5 mM). The stability of free porcine DAO was tested in a fed state simulated intestinal fluid and exhibited a half‐life period of around 19 min. A total of 50 nanokatal (nkat) free porcine DAO, which equaled the amount of enzyme isolated from around 100 g pig kidney, were necessary for the in vitro reduction of around 90% of the histamine. The dietary supplement that contains a pig kidney extract did not show DAO activity. Instead, the used histamine (0.75 mg) was apparently reduced due to the adsorption of histamine onto a capsule component by 18.9 ± 2.3% within 5 hr. Although the capsule preparation retained its overall structure and shape for at least 90 min in simulated gastric fluid, the apparent histamine reduction was significantly reduced to 12.1 ± 2.3% (P ≤ 0.05). In conclusion, an alternative to the pig kidney DAO or an improved capsule preparation is needed to ensure an adequate supplementation for histamine‐intolerant humans. Practical Application Histamine intolerance is an emerging issue in our society and the intolerance‐related physiological symptoms are currently not reliably treatable due to a lack of scientific investigation. A commercially available dietary supplement for histamine intolerance does not fulfil the requirements for a satisfactory histamine reduction in intolerant humans. The activity of the histamine degrading enzyme diamine oxidase, required for a satisfactory histamine degradation, is by far higher than the theoretical amount apparently given in the dietary supplement. With this knowledge, it is obvious that improved food supplements must be developed to help histamine intolerant humans.

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“…Among biogenic amines, histamine is the most likely to cause food poisoning (Izquierdo‐Casas et al . 2019). In this study, high percentages of histamine degradation (over 50%) were detected for sixteen strains, making these good candidates for probiotic use (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Histamine and cholesterol lowering abilities of lactic acid bacteria isolated from artisanal Pico cheese

Domingos‐Lopes

Stanton

Ross

et al. 2020

Journal of Applied Microbiology

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Aims This study was designed to select lactic acid bacteria with histamine‐ and cholesterol‐reducing abilities to be used as potential probiotics. Methods and Results Thirty strains of lactic acid bacteria isolated from an artisanal raw milk cheese were screened for their abilities to degrade histamine, reduce cholesterol and hydrolyse bile salts. Strains were also screened for safety and probiotic traits, such as resistance to gastrointestinal conditions, adhesion to Caco‐2 cells, resistance to antibiotics and presence of virulence genes. Two Lactobacillus paracasei strains presented high cholesterol‐ and histamine‐lowering abilities, tested negative for the presence of virulence genes and showed susceptibility to most important antibiotics. These strains were also shown to possess desirable in vitro probiotic properties, revealed by tolerance to gastrointestinal conditions and high adhesion to intestinal cells. Conclusions Among the screened strains, Lb. paracasei L3C21M6 revealed the best cholesterol and histamine reducing abilities together with desirable probiotic and safety features to be used in food applications. Significance and Impact of the Study The strain L3C21M6 is a good candidate for use as a probiotic with histamine‐degrading activity and cholesterol lowering effect. In addition, this strain could be use in dairy foods to prevent histamine food poisoning.

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Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial

Abstract: ISRCTN10091019; www.isrctn.org.

Cited by 48 publications

References 29 publications

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial

Evaluation of porcine diamine oxidase for the conversion of histamine in food‐relevant amounts

Histamine and cholesterol lowering abilities of lactic acid bacteria isolated from artisanal Pico cheese

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