Dialysis in the haemophilia patient: a practical approach to care

Lambing, Angela; Kuriakose, Philip; Lanzon, J.; Kachalsky, E.

doi:10.1111/j.1365-2516.2008.01872.x

Cited by 19 publications

(24 citation statements)

References 32 publications

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“…Previous research has indicated that risk factors for renal failure among individuals with hemophilia include increased age, hypertension, and HIV co-infection [1, 32]. Approximately 8% of patients in this sample had chronic renal disease, 20% of which also had HIV, and 40% of which had hypertension.…”

Section: Discussionmentioning

confidence: 78%

Multiple Comorbid Conditions among Middle-Aged and Elderly Hemophilia Patients: Prevalence Estimates and Implications for Future Care

Khleif

Rodriguez

Brown

et al. 2011

Journal of Aging Research

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Introduction. Advances in hemophilia care and treatment have led to increases in the life expectancy among hemophiliacs. As a result, persons with hemophilia are reaching an older age and experiencing various age-related health conditions never seen before in this population. Aim. To determine the prevalence of comorbidities among middle-aged and elderly hemophilia A and hemophilia B patients. Methods. Retrospective chart review among all hemophilia patients, who attended the Gulf States Hemophilia and Thrombophilia Center. Results. All patients had at least one comorbid condition other than hemophilia, and the majority had between 3 and 6 comorbidities. The most common conditions identified were chronic hepatitis C, hypertension, HIV, chronic arthropathy, and overweight/obesity. Conclusions. Since persons with comorbidities are more likely to have poorer health outcomes and require greater care in managing their health needs, caring for aging hemophiliacs is likely to pose various social and economic challenges for both patients and providers.

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Section: Discussionmentioning

confidence: 78%

Multiple Comorbid Conditions among Middle-Aged and Elderly Hemophilia Patients: Prevalence Estimates and Implications for Future Care

Khleif

Rodriguez

Brown

et al. 2011

Journal of Aging Research

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“…The general principle for RRT prescription is to treat patients with haemophilia like their age peers without haemophilia. Replacement therapy must be adapted to the baseline plasma factor deficiency and the risk of bleeding carried out by therapeutic procedures and eventually antithrombotic drugs (50). Actually, PD does not require specific prescriptions, as it does not need clotting factor replacement in relation with dialysis procedures.…”

Section: Rrt Prescriptionmentioning

confidence: 99%

Renal diseases in haemophilic patients: pathogenesis and clinical management

Esposito

Rampino

Gregorini

et al. 2013

European J of Haematology

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Haemophilia A and B are genetic X-linked bleeding disorders, caused by mutations in genes encoding factors VIII and IX, respectively. Clinical manifestations of haemophilia are spontaneous haemorrhage or acute bleeding caused by minor trauma, resulting in severe functional consequences that can culminate in a debilitating arthropathy. Life expectancy and quality of life of patients with haemophilia have dramatically improved over the last years, mainly for new therapeutic options and the awareness to the risk of HCV and HIV infections. Different clinical problems arise from this important change in history of patients with haemophilia. In particular, ageing-related diseases, such as diabetes, hypertension and cancer, and chronic viral infections are emerging as new challenges in this patient population. Among the different types of chronic illnesses, renal diseases are of special interest as they involve some difficult management issues. In fact, decisions regarding adequate preventive strategies and viral infection treatment, the choice of the dialytic modality, placement of vascular access and prescription of dialytic treatments are particularly complicated, because only few data are available. In this review, we discuss the pathogenesis of renal damage in patients with haemophilia, especially in those with blood-transmitted viral infections, and the major issues about the management of renal diseases, including problems related to dialytic treatment and kidney transplantation, providing practical algorithms to guide the clinical decision-making process.

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“…Finally, the increased risk of renal problems in elderly haemophiliacs may result in the need for dialysis. Lambing et al (2009) recently reviewed the existing literature on dialysis in haemophilia patients. Haemodialysis, through an arterio‐venous fistula or central venous catheter and peritoneal dialysis are the treatment modalities applicable to persons with haemophilia.…”

Section: Clinical Management Of Co‐morbidities In Elderly Haemophiliamentioning

confidence: 99%

Co‐morbidities and quality of life in elderly persons with haemophilia

Franchini¹,

Mannucci

2010

Br J Haematol

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SummaryThe life expectancy and quality of life of persons with haemophilia has dramatically increased since the 1970s, with the exception of the increased rate of deaths observed during the 1980s and the 1990s due to blood-borne viral infections. Improvements of factor replacement therapy, treatment of infectious diseases and comprehensive health care provided by specialised haemophilia centres are the main determinants of the increasing age of the haemophilia population. As a consequence, a growing number of these patients develop age-related co-morbidities, such as cardiovascular disease and cancer. The care of these previously rare conditions is a new challenge for caregivers in haemophilia centres. This review focuses on co-morbidities in the ageing haemophilia patients, their impact on quality of life and their complex management.

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Dialysis in the haemophilia patient: a practical approach to care

Cited by 19 publications

References 32 publications

Multiple Comorbid Conditions among Middle-Aged and Elderly Hemophilia Patients: Prevalence Estimates and Implications for Future Care

Multiple Comorbid Conditions among Middle-Aged and Elderly Hemophilia Patients: Prevalence Estimates and Implications for Future Care

Renal diseases in haemophilic patients: pathogenesis and clinical management

Co‐morbidities and quality of life in elderly persons with haemophilia

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