Dialysis Disequilibrium Syndrome and Intracranial Pressure Fluctuations in Neurosurgical Patients Undergoing Renal Replacement Therapy: Systematic Review and Pooled Analysis

Parsons, Andrew D; Sanscrainte, Chiara; Leone, Augusto; Griepp, Daniel W.; Rahme, Ralph

doi:10.1016/j.wneu.2022.11.142

Cited by 5 publications

(1 citation statement)

References 23 publications

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“…Mechanical strain on the LC and subsequent backward shifting can manifest in individuals with glaucoma, potentially resulting in damage to the optic nerve head (ONH), which encompasses the axons of ganglion cells 27 , 28 . Meanwhile, an increase in ICP has been reported in approximately 60% of patients after renal replacement therapy, including HD 29 , 30 . Ultimately, it is assumed that HD affects both IOP and ICP, and that the position of the LC can change depending on the interaction of these two pressures.…”

Section: Introductionmentioning

confidence: 99%

Hemodialysis-induced positional changes in lamina cribrosa

Kim,

Jeong,

Shin

et al. 2024

Sci Rep

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This study is aimed to investigate the effect of hemodialysis (HD) on the lamina cribrosa (LC) of the optic nerve head (ONH) using swept-source optical coherence tomography (SS-OCT) and other ophthalmological parameters in patients with end-stage kidney disease (ESKD). This prospective observational study included 29 patients who underwent HD for ESKD. ONH parameters including neural canal diameter (NCD), peripapillary vertical height (PVH), and anterior LC depth (LCD), were assessed using SS-OCT. Changes in the ONH parameters before and after HD were statistically analysed. Correlations between changes in the LCD and other ocular and systemic measurements were identified using Pearson’s correlation analyses. The mean anterior LCD significantly decreased from 441.6 ± 139.8 μm before HD to 413.5 ± 141.7 μm after HD (P = 0.001). Mean NCD and PVH did not show significant changes after HD (P = 0.841 and P = 0.574, respectively). A significant correlation was found between changes in the anterior LCD and the mean ocular perfusion pressure (r = 0.397, P = 0.036). We observed a significant decrease in anterior LCD after HD. Our study suggests that HD can influence the ONH, especially in the LC.

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