Dialysis and Hemoperfusion of Poisons and Drugs - Update

Winchester, James F.; Gelfand, Michael; Knepshield, James H.; Schreiner, George E.

doi:10.1097/00002480-197700230-00204

Cited by 152 publications

(23 citation statements)

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“…Peritoneal dialysis has been used with in creasing frequency in patients with renal fail ure [1], It is also used in the treatment of selected acute drug overdoses [2], Dialysate is infused into the patient's peritoneal cavity to allow equilibration of various metabolic waste products and uremic toxins. The fluid is then drained from the patient to a collec tion bag thus completing one dialysis cycle.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ultrafiltration on Peritoneal Dialysis Drug Clearances

et al. 1985

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To determine the effect of dialysate osmolarity on peritoneal dialysis drug transfer, peritoneal dialysis clearances of theophylline, phenobarbital, and tobramycin were determined in 10 rabbits using dialysate containing 1.5 and 4.25% glucose. Urea and creatinine clearances were also obtained for comparison. Under similar dialysis conditions, the peritoneal clearances of the three drugs remained unchanged for the two types of dialysate. In contrast, the peritoneal clearances of urea and creatinine were significantly higher with the use of 4.25 % glucose dialysate (p < 0.001). Thus, peritoneal dialysis clearances of theophylline, phenobarbital and tobramycin are not significantly affected by hypertonicity-induced ultrafiltration during acute peritioneal dialysis.

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Section: Introductionmentioning

confidence: 99%

Effect of Ultrafiltration on Peritoneal Dialysis Drug Clearances

et al. 1985

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“…once hoped to be the cure-all of toxicology, is also covered in the literature with detoxification in mind [8][9][10][11][12][13], Although largely compiled from case reports, comprehensive and critical reviews are avail able [14,15] that discuss the differential indi cation of hemodialysis and hemoperfusion.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Drug Elimination by Current Methods of Blood Purification

Pauls¹,

Grigoleit²,

Herrath³

et al. 1984

Blood Purif

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Drug elimination by extracorporeal methods (hemodialysis, hemoperfusion, hemofiltration, plasmapheresis) was investigated in an ex vivo model using banked blood. The drugs (cefotaxime, glibenclamide, isoxepac, metamizole, nomifensine, penbutolol, procainamide) showed a consistent behavior in two different concentrations. Hemodialysis showed a clear correlation between speed of elimination and size of molecules and solubility in water; plasmapheresis yielded a predictably homogeneous speed of removal with the exception of penbutolol (slow). Hemofiltration and hemoperfusion do not allow consistent prediction of results.

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“…Late, sudden deaths, presumably from dysrhyth mias, have been described. Diuresis and hemodialysis are not effective [8] and charcoal hemoperfusion probably not effective, due to the significant protein binding and large volume of distribution of the tricyclic antidepres sants in the body.…”

mentioning

confidence: 99%

Recognition and Management of Antidepressant Overdoses:Tricyclics and Trazodone

Flomenbaum

Price

1986

Neuropsychobiology

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Serious overdoses associated with tricyclic and tetracyclic antidepressants are frequently lethal. Problems associated with tricyclic antidepressant overdoses are usually the result of an acute or an acute-on-chronic overdosage. The patient who overdoses on tricyclic antidepressants may die, despite every medical effort to save him. An overdose of trazodone significantly differs from an overdose of a tricyclic antidepressant. The currently available clinical data indicate that coma and hypotension are the main concerns with trazodone overdose, and heretofore have been successfully treated with lavage, fluid therapy, and observation.

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Dialysis and Hemoperfusion of Poisons and Drugs - Update

Cited by 152 publications

References 0 publications

Effect of Ultrafiltration on Peritoneal Dialysis Drug Clearances

Effect of Ultrafiltration on Peritoneal Dialysis Drug Clearances

Comparison of Drug Elimination by Current Methods of Blood Purification

Recognition and Management of Antidepressant Overdoses:Tricyclics and Trazodone

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