Dialysate With High Dissolved Hydrogen Facilitates Dissociation of Indoxyl Sulfate From Albumin

Tange, Yoshihiro; Takesawa, Shingo; Yoshitake, Shinji

doi:10.5812/numonthly.26847

Cited by 6 publications

(3 citation statements)

References 20 publications

(17 reference statements)

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“…The initial report by Huang et al demonstrated a reduction in inflammatory markers in hemodialysis using electrolyzed water [96,97]. Furthermore, it was reported that ERW enhances dissociation of indoxyl sulfate from albumin as an underlying mechanism [98]. However, widespread recognition of this treatment system did not occur.…”

Section: Clinical Studies Using Ehw For Hemodialysismentioning

confidence: 99%

Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View

Nakayama,

Kabayama,

Miyazaki

2024

Antioxidants

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Chronic kidney disease (CKD), which is globally on the rise, has become an urgent challenge from the perspective of public health, given its risk factors such as end-stage renal failure, cardiovascular diseases, and infections. The pathophysiology of CKD, including dialysis patients, is deeply associated with enhanced oxidative stress in both the kidneys and the entire body. Therefore, the introduction of a safe and widely applicable antioxidant therapy is expected as a measure against CKD. Electrolyzed hydrogen water (EHW) generated through the electrolysis of water has been confirmed to possess chemical antioxidant capabilities. In Japan, devices producing this water have become popular for household drinking water. In CKD model experiments conducted to date, drinking EHW has been shown to suppress the progression of kidney damage related to hypertension. Furthermore, clinical studies have reported that systemic oxidative stress in patients undergoing dialysis treatment using EHW is suppressed, leading to a reduction in the incidence of cardiovascular complications. In the future, considering EHW as one of the comprehensive measures against CKD holds significant importance. The medical utility of EHW is believed to be substantial, and further investigation is warranted.

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Section: Clinical Studies Using Ehw For Hemodialysismentioning

confidence: 99%

Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View

Nakayama,

Kabayama,

Miyazaki

2024

Antioxidants

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“…Moreover, high sodium concentrations in the substituate of predilution HDF at increased plasma ionic strength could improve PBUT removal ( Krieter et al, 2017 ). In addition, some studies have found that the use of high dissolved hydrogen dialysate can promote the dissociation of IS from the albumin binding site, increase the level of free IS and improving the scavenging effect of IS in the filtrate ( Tange et al, 2015 ).…”

Section: Metabolism and Elimination Of Uremic Toxinsmentioning

confidence: 99%

Derivation and elimination of uremic toxins from kidney-gut axis

Shi

et al. 2023

Front. Physiol.

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Uremic toxins are chemicals, organic or inorganic, that accumulate in the body fluids of individuals with acute or chronic kidney disease and impaired renal function. More than 130 uremic solutions are included in the most comprehensive reviews to date by the European Uremic Toxins Work Group, and novel investigations are ongoing to increase this number. Although approaches to remove uremic toxins have emerged, recalcitrant toxins that injure the human body remain a difficult problem. Herein, we review the derivation and elimination of uremic toxins, outline kidney–gut axis function and relative toxin removal methods, and elucidate promising approaches to effectively remove toxins.

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“…Another area of research concerns altering the dialysis milieu in order to affect the binding of URS to plasma proteins. Examples of this effort which have data supporting their use include using hypertonic solution, the use of albumin-binding site competitors such as tryptophan and docosahexaenoic acid, increasing temperature, plasma dilutions, and pH manipulation of the dialysate [47,[90][91][92][93][94].…”

Section: Dialysismentioning

confidence: 99%

Uremic Retention Solutes

Ackley¹,

Soiefer²,

Etinger³

et al. 2018

Aspects in Dialysis

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This chapter will address the broad subject of uremic retention solutes (URS), also known as uremic toxins. Some of these solutes had been recognized for decades, and in 1999 when the European Uremic Toxin Work Group was established, a fuller description of URS was presented. The group sought to identify and characterize the solutes in the serum of patients with impaired glomerular filtration, in order to explore their role in the pathogenesis of the uremic syndrome and improve current therapeutic options. This chapter will review the different types of URS, as well as the adverse effects associated with their accumulation. It will also cover current and potential therapeutic approaches to reduce their levels.

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Dialysate With High Dissolved Hydrogen Facilitates Dissociation of Indoxyl Sulfate From Albumin

Cited by 6 publications

References 20 publications

Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View

Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View

Derivation and elimination of uremic toxins from kidney-gut axis

Uremic Retention Solutes

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