Diallyl trisulfide sensitizes radiation therapy on glioblastoma through directly targeting thioredoxin 1

Tian, Yangyang; Ge, Zehe; Xu, Mingwei; Zhao, Mengjie; Ding, Fangshu; Yin, Jianxing; Wang, Xiuxing; You, Yongping; Shi, Zhumei; Qian, Xu

doi:10.1016/j.freeradbiomed.2022.07.019

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…Furthermore, DAST has been shown to enhance irradiation (IR)-induced ROS accumulation, apoptosis, and DNA damage, and inhibit tumor growth of GBM cells as well. These observations suggest the utility of DATS in sensitizing radiotherapy to GBM patients [142].…”

Section: Diallyl Trisulfide (Dast)mentioning

confidence: 76%

The Importance of Thioredoxin-1 in Health and Disease

et al. 2023

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Thioredoxin-1 (Trx-1) is a multifunctional protein ubiquitously found in the human body. Trx-1 plays an important role in various cellular functions such as maintenance of redox homeostasis, proliferation, and DNA synthesis, but also modulation of transcription factors and control of cell death. Thus, Trx-1 is one of the most important proteins for proper cell and organ function. Therefore, modulation of Trx gene expression or modulation of Trx activity by various mechanisms, including post-translational modifications or protein–protein interactions, could cause a transition from the physiological state of cells and organs to various pathologies such as cancer, and neurodegenerative and cardiovascular diseases. In this review, we not only discuss the current knowledge of Trx in health and disease, but also highlight its potential function as a biomarker.

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Section: Diallyl Trisulfide (Dast)mentioning

confidence: 76%

The Importance of Thioredoxin-1 in Health and Disease

et al. 2023

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“…Also, in our previous work performed on colorectal cancer cells, IC50 of PTX was in the nanomolar range, and IC50 of GYY4137 was in the micromolar range, showing a low toxicity of GYY4137 after 24h treatment [ 9 ]. Since GYY4137 and other sulfide donors were already shown to potentiate apoptosis in cancer cells [ 31 , 32 , 33 ], we first evaluated the effect of GYY4137 on the level of apoptosis. Co-treatment of GYY4137 with PTX potentiated apoptosis in MDA-MB-231 cells, but not in JIMT1 cells, thus pointing to the diverse effect of exogenous H 2 S on different types of breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Slow Sulfide Donor GYY4137 Increased the Sensitivity of Two Breast Cancer Cell Lines to Paclitaxel by Different Mechanisms

Liskova,

Chovancova,

Galvankova

et al. 2024

Biomolecules

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Paclitaxel (PTX) is a chemotherapeutic agent affecting microtubule polymerization. The efficacy of PTX depends on the type of tumor, and its improvement would be beneficial in patients’ treatment. Therefore, we tested the effect of slow sulfide donor GYY4137 on paclitaxel sensitivity in two different breast cancer cell lines, MDA-MB-231, derived from a triple negative cell line, and JIMT1, which overexpresses HER2 and is resistant to trastuzumab. In JIMT1 and MDA-MB-231 cells, we compared IC50 and some metabolic (apoptosis induction, lactate/pyruvate conversion, production of reactive oxygen species, etc.), morphologic (changes in cytoskeleton), and functional (migration, angiogenesis) parameters for PTX and PTX/GYY4137, aiming to determine the mechanism of the sensitization of PTX. We observed improved sensitivity to paclitaxel in the presence of GYY4137 in both cell lines, but also some differences in apoptosis induction and pyruvate/lactate conversion between these cells. In MDA-MB-231 cells, GYY4137 increased apoptosis without affecting the IP3R1 protein, changing the morphology of the cytoskeleton. A mechanism of PTX sensitization by GYY4137 in JIMT1 cells is distinct from MDA-MB-231, and remains to be further elucidated. We suggest different mechanisms of action for H2S on the paclitaxel treatment of MDA-MB-231 and JIMT1 breast cancer cell lines.

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“…This strategy aims to enhance the drugs' specificity in application. For instance, Trx1 inhibitors may exhibit heightened efficacy against cancer that rely on Trx1 for survival and proliferation, while Trx2 inhibitors could be more effective against certain ND resulting from mitochondrial dysfunction and oxidative stress [ 282 , 377 ]. The final objective is to optimize the utilization of predictive factors prior to treatment, thereby facilitating a more comprehensive evaluation of the expression and activity disparities among Trx system constituents in both normal and pathological cells.…”

Section: Therapeutic Potential Of Trx Proteins In Aging Diseasesmentioning

confidence: 99%

“… Diallyl trisulfide (DATS)→Trx1→Glioblastoma Sorafenib→Trx1→Hepatocellular carcinoma (NCT00618384, NCT01029418, NCT01029418, NCT00892658, NCT00846131, NCT00846131, etc.) [ 487 ] [ 377 ] [ 488 ] TrxR TrxR-interfering drug delivery system (based on RGD-PEG-PUSeSe-PEG-RGD self-assembling micelles)→TrxR→Cancer Se-methylselenocysteine (SMC)→TrxR→AD (NCT01497431, etc.) Butaselen (BS)→TrxR1→Hepatocellular carcinoma BBSKE (Ethaselen)→TrxR1→Cancer ACZ2→TrxR1→Gastric cancer Ethaselen→TrxR1→Lung cancer [ 360 ] [ 489 ] [ 490 ] [ 491 ] [ 492 ] [ 493 ] Michael receptor TrxR [ 6 ]-dehydroshogaol→TrxR→Cancer DVD-445 and its extended analogues→TrxR→Cancer [ 494 ] [ 495 ] Quinazoline derivatives TXNIP Quinazoline derivatives (D-2 & C-1)→TXNIP→Diabetes [ 496 ] Imidazole derivatives Trx1 PX-12 (1-methylpropyl 2-imidazolyl disulfide)→Trx1→Cancer [ 497 ] Benzopyrane derivatives Trx & TrxR SIMR1281→Trx & TrxR→Cancer [ 498 ] Other compounds and therapeutic methods Trx Ac-Cys-Pro-Cys-amide (thioredoxin-mimetic peptide)→Atherosclerosis …”

Section: Therapeutic Potential Of Trx Proteins In Aging Diseasesmentioning

confidence: 99%

Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases

Yang,

Lin,

Huang

et al. 2024

Redox Biology

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Diallyl trisulfide sensitizes radiation therapy on glioblastoma through directly targeting thioredoxin 1

Cited by 6 publications

References 62 publications

The Importance of Thioredoxin-1 in Health and Disease

The Importance of Thioredoxin-1 in Health and Disease

Slow Sulfide Donor GYY4137 Increased the Sensitivity of Two Breast Cancer Cell Lines to Paclitaxel by Different Mechanisms

Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases

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