Diallyl trisulfide reduced the reproductive capacity of male Sitotroga cerealella via the regulation of juvenile and ecdysone hormones

Shah, Sakhawat; Zhang, Susu; Elgizawy, Karam Khamis; Yan, Wen-Han; Tang, Ning; Wu, Gang; Yang, Feng-Lian

doi:10.1016/j.ecoenv.2022.114304

Cited by 9 publications

(6 citation statements)

References 39 publications

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“…JHMAT is an enzyme that catalyzes the conversion of inactive precursors of JH to active JH in the final stages of JH biosynthesis (36, 38). Interestingly, while it has not been previously implicated in pesticide resurgence, treatment of the stored product pest Sitotroga cerealella with diallyl trisulfide, an insecticidal compound in garlic essential oil, was found to increase JHAMT mRNA levels (72). Because JHMAT is the key rate-limiting enzyme in regulation of JH titer our results suggest that its enhanced expression is a key molecular mechanism of pesticide resurgence in BPH.…”

Section: Discussionmentioning

confidence: 99%

Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

Gao,

Su,

Liu

et al. 2023

Preprint

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Pesticide-induced resurgence, increases in pest insect populations following pesticide application, is a serious threat to the sustainable control of many highly damaging crop pests. Resurgence can result from pesticide-enhanced pest reproduction, however, the molecular mechanisms mediating this process remain unresolved. Here we show that brown planthopper (BPH) resurgence following emamectin benzoate (EB) exposure results from the coordinated action of a diverse suite of actors that regulate juvenile hormone (JH) levels, resulting in increased JH titer in adult females and enhanced fecundity. Following reports of BPH resurgence in rice crops when this species is exposed to EB, we demonstrate that EB treatment results in profound changes in female BPH fitness including enhanced ovary development and elevated egg production. This enhanced reproductive fitness results from the EB-mediated upregulation of key genes involved in the regulation of JH, including JHAMT, Met and Kr-h1 and the downregulation of allatostatin (AstA) and allatostatin receptor (AstAR) expression. The remodulation of gene expression following EB exposure is dependent on the action of this insecticide on its molecular target the glutamate-gated chloride channel (GluCl) receptor. Collectively, these results provide mechanistic insights into the regulation of negative pesticide-induced responses in insects and reveal the key actors involved in the JH-signaling pathway that underpin pesticide resurgence.

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Section: Discussionmentioning

confidence: 99%

Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

Gao,

Su,

Liu

et al. 2023

Preprint

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“…Apart from these medicinal applications, DAT has insecticidal activities, such as repellent, oviposition inhibitor, and spermicidal activity against S. cerealella [10]. Previously we reported that DAT decreased the dichotomous sperm numbers and testis protein contents of S. cerealella and impaired the juvenile and ecdysone hormone titers, resulting in lesser oviposition [11]. We further showed that DAT is associated with oligoasthenoteratospermia (OAT), which includes morphological and ultrastructural alterations in dimorphic sperm structure, reduced sperm motility, and arrested spermatogenesis [12].…”

Section: Of 15mentioning

confidence: 99%

Diallyl Trisulfide Causes Male Infertility with Oligoasthenoteratospermia in Sitotroga cerealella through the Ubiquitin–Proteasome Pathway

Shah,

Elgizawy,

et al. 2023

Cells

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Essential oils extracted from plant sources along with their biologically active components may have negative effects on insects. Diallyl trisulfide (DAT) is an active component of garlic essential oil, and it exhibits multi-targeted activity against many organisms. Previously we reported that DAT induces male infertility and leads to apyrene and eupyrene sperm dysfunction in Sitotroga cerealella. In this study, we conducted an analysis of testis-specific RNA-Seq data and identified 449 downregulated genes and 60 upregulated genes in the DAT group compared to the control group. The downregulated genes were significantly enriched in the ubiquitin–proteasome pathway. Furthermore, DAT caused a significant reduction in mRNA expression of proteasome regulatory subunit particles required for ATP-dependent degradation of ubiquitinated proteins as well as decreased the expression profile of proteasome core particles, including β1, β2, and β5. Sperm physiological analysis showed that DAT decreased the chymotrypsin-like activity of the 20S proteasome and formed aggresomes in spermatozoa. Overall, our findings suggest that DAT impairs the testis proteasome, ultimately causing male infertility characterized by oligoasthenoteratospermia due to disruption in sperm proteasome assembly in S. cerealella.

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“…9 Moreover, botanical insecticides possess favorable characteristics such as reduced persistence in the environment, target specificity, and multiple modes of action. 10,11 However, the volatility and rapid vaporization of EOs and their active components have limited their effectiveness in long-term storage environments. To address this limitation, microencapsulation technology has emerged as a promising approach to enhance the insecticidal efficacy of EOs.…”

Section: Introductionmentioning

confidence: 99%

Microcapsules of mesoporous silica and cyclodextrin modified loaded with nonanal and decanal for effective control of Sitotroga cerealella in grain storage environments

Shah,

Zhang,

et al. 2024

Pest Management Science

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BACKGROUNDThe Angoumois grain moth, Sitotroga cerealella, is a destructive pest of maize, wheat, and rice, causing economic losses and threatening food security. This study aimed to develop and characterize microcapsules of mesoporous silica nanospheres (MSN) and cyclodextrin‐modified mesoporous silica nanospheres (CDMSN) containing two aldehydes, nonanal and decanal, found in plant essential oils, to assess their attractiveness to S. cerealella populations.RESULTSMicrocapsules with 2:1 ratio of nonanal and decanal exhibited an average encapsulation efficiency of 39.82% for MSN loaded with nonanal and decanal (MSN‐ND) and 46.10% for CDMSN loaded with nonanal and decanal (CDMSN‐ND). They have an elliptical shape with particle sizes of 115 nm for MSN and 175 nm for CDMSN. Gas chromatography–mass spectrometry analysis revealed in vitro release of nonanal in MSN at 96.24% and decanal at 96.42% by the 36th day. CDMSN showed releases of 93.83% for nonanal and 93.74% for decanal by the 50th day. CDMSN‐ND attracted adult S. cerealella for 43 days, while MSN‐ND remained effective for 29 days. In mass trapping assays in simulated grain warehouse, both MSN‐ND and CDMSN‐ND trapped over 50% of the adult population within 7 days, significantly reducing grain infestation rates below 10% by inhibiting F1 adult emergence. At temperatures ranging from 20 °C to 35 °C, both microcapsules exhibited significant and effective attraction rates for S. cerealella. Stored wheat seeds treated with CDMSN and CDMSN‐ND over 1 year showed no significant differences in key germination parameters.CONCLUSIONMicroencapsulated nonanal and decanal offer a promising, sustainable approach for controlling S. cerealella infestation in stored grains, contributing to global food security. © 2024 Society of Chemical Industry.

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Diallyl trisulfide reduced the reproductive capacity of male Sitotroga cerealella via the regulation of juvenile and ecdysone hormones

Cited by 9 publications

References 39 publications

Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

Diallyl Trisulfide Causes Male Infertility with Oligoasthenoteratospermia in Sitotroga cerealella through the Ubiquitin–Proteasome Pathway

Microcapsules of mesoporous silica and cyclodextrin modified loaded with nonanal and decanal for effective control of Sitotroga cerealella in grain storage environments

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