Diallyl Trisulfide Is More Cytotoxic to Prostate Cancer Cells PC-3 than to Noncancerous Epithelial Cell Line PNT1A: A Possible Role of p66Shc signaling Axis

Borkowska, Andzelika; Knap, Narcyz; Antosiewicz, Jędrzej

doi:10.1080/01635581.2013.789115

Cited by 32 publications

(19 citation statements)

References 18 publications

(26 reference statements)

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“…Similarly, DATS, a major organosulfur compound isolated from garlic, can inhibit cell proliferation through the cell cycle arrest or the induction of apoptosis [63]. DATS showed high toxicity toward prostate cancer cells [64], while DADS induced apoptosis in HL-60, HCT-15, and neuroblastoma cells [65][66][67]. It also induced apoptosis in COLO 25 cell line by promoting caspase-3 activity [68].…”

Section: Antiproliferative Activity Of a Cornutum And A Cepa Extractsmentioning

confidence: 99%

Comparison of Organosulfur and Amino Acid Composition between Triploid Onion Allium cornutum Clementi ex Visiani, 1842, and Common Onion Allium cepa L., and Evidences for Antiproliferative Activity of Their Extracts

Fredotović

Soldo

Šprung

et al. 2020

Plants

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Species that belong to the genus Allium have been widely used for human food and traditional medicine. Their beneficial health effects, as well as the specific aroma, are associated with their bioactive chemical compounds, such as sulfur compounds and flavonoids. Gas chromatography and mass spectrometry (GC-MS) and reverse-phase high-performance liquid chromatography (reverse-phase HPLC) were used to identify organosulfur and amino acid content of triploid hybrid onion, Allium cornutum Clement ex Visiani, 1842, and common onion, Allium cepa L. Allium extracts were tested for their antiproliferative activity in three human cancer cell lines (HeLa, HCT116, and U2OS). DNA fragmentation and DAPI staining analysis were performed on HeLa cells to evaluate the effect of extracts on DNA damage and cell morphology. The mRNA expression of p53, Bax, and Caspase-3 genes involved in apoptosis were analyzed by real-time PCR. Using GC-MS, 27 compounds were found in two Allium species headspaces. Differences were noted among the main compound abundance in the headspace (although the major thiols and disulfides were qualitatively identic in both Allium species) and dipropyl disulfide, diisopropyl trisulfide, and (Z)-prop-1-enyl propyl trisulfide were predominant sulfides. Identification of amino acids and their quantities were determined by reverse-phase HPLC. Most abundant amino acids in both onions were arginine (Arg) and glutamic acid (Glu). The results of cytotoxicity testing confirmed antiproliferative effects of both species. The DNA fragmentation assay, DAPI staining and real time PCR analysis confirmed that A. cornutum and A. cepa extracts induced apoptosis in HeLa cells. This study presents the evidence for possible therapeutic use of A. cornutum and A. cepa extracts against human cervical carcinoma cell line.

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Section: Antiproliferative Activity Of a Cornutum And A Cepa Extractsmentioning

confidence: 99%

Comparison of Organosulfur and Amino Acid Composition between Triploid Onion Allium cornutum Clementi ex Visiani, 1842, and Common Onion Allium cepa L., and Evidences for Antiproliferative Activity of Their Extracts

Fredotović

Soldo

Šprung

et al. 2020

Plants

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“…Several studies have shown that DATS induces G2/M phase cell cycle arrest [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. DATS has been shown to induce cell cycle arrest by enhancing generation of reactive oxygen species (ROS) [ 33 , 34 , 43 , 45 , 47 ]. One pathway of ROS generation begins with degradation of the iron storage protein ferritin, which has been shown following DATS treatment, leading to an increase in labile iron pool (LIP) size [ 43 , 47 , 48 ].…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment

Puccinelli

Stan

2017

IJMS

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Bioactive dietary agents have been shown to regulate multiple cancer hallmark pathways. Epidemiologic studies have linked consumption of Allium vegetables, such as garlic and onions, to decreased incidence of cancer. Diallyl trisulfide (DATS), a bioactive compound derived from Allium vegetables, has been investigated as an anti-cancer and chemopreventive agent. Preclinical studies provide ample evidence that DATS regulates multiple cancer hallmark pathways including cell cycle, apoptosis, angiogenesis, invasion, and metastasis. DATS has been shown to arrest cancer cells at multiple stages of the cell cycle with the G2/M arrest being the most widely reported. Additionally, increased pro-apoptotic capacity as a result of regulating intrinsic and extrinsic apoptotic pathway components has been widely reported following DATS treatment. Invasion, migration, and angiogenesis represent emerging targets of DATS and support its anti-cancer properties. This review summarizes DATS mechanisms of action as an anti-cancer and chemopreventive agent. These studies provide rationale for future investigation into its use as a cancer chemopreventive agent.

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“…The consumption of allium vegetables, especially garlic have been linked to reduced risk of multiple cancers [74] especially prostate cancer [75,76]. As for many of the other natural compounds, multiple mechanisms of action, including suppressing inflammation, suppressing activity of NfκB and altering cell signaling pathways have been identified for the organosulfur compounds [74,76].…”

Section: Introductionmentioning

confidence: 99%

“…As for many of the other natural compounds, multiple mechanisms of action, including suppressing inflammation, suppressing activity of NfκB and altering cell signaling pathways have been identified for the organosulfur compounds [74,76]. …”

Section: Introductionmentioning

confidence: 99%

Diet components can suppress inflammation and reduce cancer risk

Hardman

2014

Nutr Res Pract

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Epidemiology studies indicate that diet or specific dietary components can reduce the risk for cancer, cardiovascular disease and diabetes. An underlying cause of these diseases is chronic inflammation. Dietary components that are beneficial against disease seem to have multiple mechanisms of action and many also have a common mechanism of reducing inflammation, often via the NFκB pathway. Thus, a plant based diet can contain many components that reduce inflammation and can reduce the risk for developing all three of these chronic diseases. We summarize dietary components that have been shown to reduce cancer risk and two studies that show that dietary walnut can reduce cancer growth and development. Part of the mechanism for the anticancer benefit of walnut was by suppressing the activation of NFκB. In this brief review, we focus on reduction of cancer risk by dietary components and the relationship to suppression of inflammation. However, it should be remembered that most dietary components have multiple beneficial mechanisms of action that can be additive and that suppression of chronic inflammation should reduce the risk for all three chronic diseases.

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Diallyl Trisulfide Is More Cytotoxic to Prostate Cancer Cells PC-3 than to Noncancerous Epithelial Cell Line PNT1A: A Possible Role of p66Shc signaling Axis

Cited by 32 publications

References 18 publications

Comparison of Organosulfur and Amino Acid Composition between Triploid Onion Allium cornutum Clementi ex Visiani, 1842, and Common Onion Allium cepa L., and Evidences for Antiproliferative Activity of Their Extracts

Comparison of Organosulfur and Amino Acid Composition between Triploid Onion Allium cornutum Clementi ex Visiani, 1842, and Common Onion Allium cepa L., and Evidences for Antiproliferative Activity of Their Extracts

Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment

Diet components can suppress inflammation and reduce cancer risk

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