Diallel cross in swine production: A review

Okoro, V. M. O.; Mbajiorgu, C. A.

doi:10.18805/ijar.v0iof.7603

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…Diallels have long history in quantitative genetics, having been used originally in plant breeding studies to judge the relative merits of different strain combinations and subsequently for gaining insight into the heritable architecture of a broad range of phenotypes ( e.g. , refs in Christie and Shattuck 1992; Lenarcic et al 2012; Okoro and Mbajiorgu 2017), including host-pathogen interactions in, e.g. , crickets (Rantala and Roff 2006), flies (Wayne et al 2011), and insects (Pereira et al 2015) (see Methods and Discussion for connections to other diallel literature).…”

Section: Introductionmentioning

confidence: 99%

Diallel analysis revealsMx1-dependent andMx1-independent effects on response to influenza A virus in mice

Maurizio

Ferris

Keele

et al. 2017

Preprint

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Influenza A virus (IAV) is a respiratory pathogen that causes substantial morbidity and mortality during both seasonal and pandemic 1 outbreaks. Infection outcomes in unexposed populations are affected by host genetics, but this host genetic architecture is not well 2 understood. Here we obtain a broad view of how heritable factors affect a mouse model of response to IAV infection using an 8×8 diallel 3 of the eight inbred founder strains of the Collaborative Cross (CC). Expanding on a prior statistical framework for modeling treatment 4 response in diallels, we explore how a range of heritable effects modify acute host response to IAV through 4 days post-infection. Heritable 5 effects in aggregate explained about 57% of the variance in IAV-induced weight loss. Much of this was attributable to a pattern of additive 6 effects that became more prominent through day 4 post-infection and was consistent with previous reports of anti-influenza myxovirus 7 resistance 1 (Mx1) polymorphisms segregating between these strains; the additive effects largely recapitulated haplotype effects observed 8 at the Mx1 locus in a previous study of the incipient CC (pre-CC), and are also replicated here in a CC recombinant intercross (CC-RIX) 9 population. Genetic dominance of protective Mx1 haplotypes was observed to differ by subspecies origin: relative to the domesticus null 10 Mx1 allele, musculus acts dominantly whereas castaneus acts additively. After controlling for Mx1, heritable effects, though less distinct, 11 accounted for about 34% of the phenotypic variance. Implications for future mapping studies are discussed. 12Keywords: treatment response, multiparental population, causal effect, Bayesian model, multiple imputation ARTICLE SUMMARY 14Seasonal and pandemic influenza viruses comprise an important public health burden, but the architecture of host genetic resistance to 15 viruses is poorly understood. We conducted an influenza challenge in a diallel cross of eight inbred mouse strains. Roughly 60% of variation 16 in disease at 4 days post-infection was explained by genetic and non-genetic diallel effects, with about 34% of variation independent of the 17 host resistance factor, Mx1. The dominance of Mx1 resistance was highly dependent on subspecies Mx1 allelic origin, and similar Mx1 18 effect patterns were found in the related Collaborative Cross strains, motivating integrated infection studies in these populations.

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Section: Introductionmentioning

confidence: 99%

Diallel analysis revealsMx1-dependent andMx1-independent effects on response to influenza A virus in mice

Maurizio

Ferris

Keele

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…Diallels have a long history in quantitative genetics, having been used originally in plant breeding studies to judge the relative merits of different strain combinations and subsequently for gaining insight into the heritable architecture of a broad range of phenotypes [ e.g. , references in Christie and Shattuck (1992) , Lenarcic et al (2012) , and Okoro and Mbajiorgu (2017) ], including host–pathogen interactions in, e.g. , crickets ( Rantala and Roff 2006 ) and flies ( Wayne et al 2011 ) (see Statistical Models and Methods and Discussion for connections to other diallel literature).…”

mentioning

confidence: 99%

Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice

Maurizio

Ferris

Keele

et al. 2018

G3 Genes|Genomes|Genetics

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Influenza A virus (IAV) is a respiratory pathogen that causes substantial morbidity and mortality during both seasonal and pandemic outbreaks. Infection outcomes in unexposed populations are affected by host genetics, but the host genetic architecture is not well understood. Here, we obtain a broad view of how heritable factors affect a mouse model of response to IAV infection using an 8 × 8 diallel of the eight inbred founder strains of the Collaborative Cross (CC). Expanding on a prior statistical framework for modeling treatment response in diallels, we explore how a range of heritable effects modify acute host response to IAV through 4 d postinfection. Heritable effects in aggregate explained ∼57% of the variance in IAV-induced weight loss. Much of this was attributable to a pattern of additive effects that became more prominent through day 4 postinfection and was consistent with previous reports of antiinfluenza myxovirus resistance 1 (Mx1) polymorphisms segregating between these strains; these additive effects largely recapitulated haplotype effects observed at the Mx1 locus in a previous study of the incipient CC, and are also replicated here in a CC recombinant intercross population. Genetic dominance of protective Mx1 haplotypes was observed to differ by subspecies of origin: relative to the domesticus null Mx1 allele, musculus acts dominantly whereas castaneus acts additively. After controlling for Mx1, heritable effects, though less distinct, accounted for ∼34% of the phenotypic variance. Implications for future mapping studies are discussed.

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“…However, this expansion is a double-edged sword. While it provides material abundance, it also creates numerous problems that are of concern to human civilization (Okoro et al, 2017).…”

Section: The Positive and Negative Effects Of Globalizationmentioning

confidence: 99%

Development of Business Law in the Perspective of Pancasila in the Era of Industrial Revolution 4.0

Gunartha,

Yustiawan

2023

POLRI

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This article aims to explore the development of business law in the context of Pancasila during the era of the Industrial Revolution 4.0. The research methodology used is normative juridical, which examines the implementation of positive legal provisions in business law. The data used includes primary and secondary sources, obtained from legal products related to business and trade. The rapid globalization brought by the 21st century industrial revolution has resulted in significant changes in various aspects of law, politics, economics, technology, and culture. As the Industrial Revolution 4.0 relies heavily on telematics (telecommunications, media, and information), it is essential to adjust regulations in the field of business law to accommodate these changes. The Indonesian government must engage in legal development, legal harmonization, and legal reconstruction to update legal products in line with the global situation. This includes building a legal system that reflects Pancasila and the 1945 Constitution to adapt to the industrial era 4.0. As the development of business law in the Industrial 4.0 era must be consistent with Pancasila's values and the 1945 Constitution, it is crucial to prioritize these values in legal development.

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Diallel cross in swine production: A review

Cited by 5 publications

References 38 publications

Diallel analysis revealsMx1-dependent andMx1-independent effects on response to influenza A virus in mice

Diallel analysis revealsMx1-dependent andMx1-independent effects on response to influenza A virus in mice

Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice

Development of Business Law in the Perspective of Pancasila in the Era of Industrial Revolution 4.0

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