Diallel Cross Analysis of Body Weight in Subspecies of Mice.

Abstract

A complete 4 x 4 diallel cross of CF#1 (C), C57BL/6NCrj (B) C3H/HeNCrj (H) and Yonakuni wild mice (Y, Mus musculus molossinus yonakuni) has been conducted to estimate the effects of sex, degree of heterosis, general combining ability (gca), specific combining ability (sca), maternal ability, and reciprocal cross on body weight at 1 (Wk1), 3 (Wk3), 6 (Wk6) and 10 (Wk10) weeks of age. A least squares analysis was performed on 828 mice and all sources of variation showed significant effects (P < 0.01) on body weight but not sex at Wk1 (P > 0.05). Males were heavier than females (P < 0.01) at Wk3, Wk6 and Wk10. C and Y were the heaviest and lightest in body weight, whereas H and B were intermediate. Differences in body weight were observed between linebred and linecross at all ages studied: 6.57%, 10.22%, 8.70% and 5.89% heterosis for the respective ages. The degree of gca and maternal effects can be ranked as C > H > B > Y. Crossing between C and H had greater sca than other combinations at all ages studied, whereas B x Y had the smallest. Mean body weight of the offspring from two-line reciprocal cross differed according to their dam. A relatively large proportion of additive genetic effects in contributing to the variation in offspring body weight was indicated.

Craniomandibular form and body size variation of first generation mouse hybrids: A model for hominin hybridization

“…Taken together, and based on previous definitions (Chai, 1956b), these results suggest that the F 1 mouse hybrids examined here can be considered transgressive (more extreme; in this case, larger than parents) in terms of the postcranial skeletal elements measured here. The results of comparisons of body size (limb length) and overall cranial size—i.e., that hybrids, by and large, have larger crania and longer limbs—are consistent with previous studies of mouse hybrids (Eaton, 1953; Chai, 1956b; Carmon, 1963; Leamy, 1982a; Thorpe and Leamy, 1983; Kurnianto et al, 1999; Pallares Amaya, 2015; Pallares et al, 2016; Percival et al, 2016). It is important to note that although these previous studies, like the present study, used strains representing subspecies of Mus musculus , not all strains (or even subspecies) included in the previous work are identical to those used in this study.…”

Somatic development and embryo yield in crossbred F1 mice generated by different mating strategies

“…to the others strains used, a trait possibly related to a larger number of ovulations in natural cycles, since the effect was independent of the male strain used. The litter size range observed for the different strains used was similar to those reported in other studies for colonies in good health conditions (Festing, 1976;Davis et al, 1991;Kurnianto et al, 1999). The greater litter size of the Swiss dam, however, facilitates the establishment of F1 experimental populations.…”

Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross

“…; Kurnianto et al. ) and have longer craniofacial linear distances, except for certain skull width measures (Leamy, ). Our results provide further evidence for this inbreeding effect on mouse skull size.…”