Dialkyl Mesoxalates by Ozonolysis of Dialkyl Benzalmalonates: Dimethyl Mesoxalate

Tietze, Lutz F.; Bratz, Matthias

doi:10.1002/0471264180.os071.27

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…IR spectra were recorded in the FT-mode. 1 H NMR spectra were recorded at 400 MHz. 13 C NMR spectra were recorded at 100.6 MHz.…”

Section: Methodsmentioning

confidence: 99%

“…1,1-Diethyl 2-t-butyl ethenetricarboxylate (1a) (reference 2 in the text) and 1,1-dibenzyl 2-tbutyl ethenetricarboxylate (1c) (reference 3d in the text) were prepared according to the literature . 1b, 1d and 3a-b were prepared by the reaction of the corresponding ketomalonate 1 with the corresponding (triphenylphosphoranylidene)acetate according to the preparation of 1a. 1b (87%): R f = 0.7 (hexane-ether = 1 : 1).…”

Section: Methodsmentioning

confidence: 99%

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Novel Lactonization of Ethenetricarboxylate Derivatives: Intermolecular Trapping of Alkenes.

et al. 2005

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2005 Furan derivatives R 0060Novel Lactonization of Ethenetricarboxylate Derivatives: Intermolecular Trapping of Alkenes. -An unprecedented cyclization of the title compounds takes place by trapping of alkenes generated in situ in the presence of a Lewis acid such as SnCl4. γ-Lactone products are formed in high yields. The reaction of predeprotected carboxylic acid (VI) and various alkenes in the presence of SnCl4 yields a variety of γ-lactones in good yields. The use of a catalytic amount of SnCl 4 is also tested but affords mostly lower yields. Other Lewis acids can be used as well: in some cases the products are obtained in higher diastereoselectivity but mostly on the cost of the yield. -(YAMAZAKI*, S.; OHMITSU, K.; OHI, K.; OTSUBO, T.; MORIYAMA, K.; Org. Lett. 7 (2005) 5, 759-762; Dep. Chem., Nara Univ. Educ., Takabatake, Nara 630, Japan; Eng.) -Steudel 29-116

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“…IR spectra were recorded in the FT-mode. 1 H NMR spectra were recorded at 400 MHz. 13 C NMR spectra were recorded at 100.6 MHz.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Novel Lactonization of Ethenetricarboxylate Derivatives: Intermolecular Trapping of Alkenes.

et al. 2005

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“…A double bond-substituted amino acid, can be oxidised [71] and then it is easy converted in the relative 1,3-dipole by functional group interconversion (Scheme 26) [72,73].…”

Section: Stapled Peptidesmentioning

confidence: 99%

Stapled Peptides—A Useful Improvement for Peptide-Based Drugs

2019

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Peptide-based drugs, despite being relegated as niche pharmaceuticals for years, are now capturing more and more attention from the scientific community. The main problem for these kinds of pharmacological compounds was the low degree of cellular uptake, which relegates the application of peptide-drugs to extracellular targets. In recent years, many new techniques have been developed in order to bypass the intrinsic problem of this kind of pharmaceuticals. One of these features is the use of stapled peptides. Stapled peptides consist of peptide chains that bring an external brace that force the peptide structure into an α-helical one. The cross-link is obtained by the linkage of the side chains of opportune-modified amino acids posed at the right distance inside the peptide chain. In this account, we report the main stapling methodologies currently employed or under development and the synthetic pathways involved in the amino acid modifications. Moreover, we report the results of two comparative studies upon different kinds of stapled-peptides, evaluating the properties given from each typology of staple to the target peptide and discussing the best choices for the use of this feature in peptide-drug synthesis.

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“…Dengan pencahayaan ultraviolet kebanyakan polutan organik dapat dioksidasi menjadi CO 2 dan H 2 O [3] dan selain itu adalah metoda ozonolisis. Ozonolisis merupakan suatu metoda degradasi senyawa organik dengan menggunakan ozon (O 3 ), ISSN : 1978-628X / eISSN : 2476-8960 109 dimana terjadi pemecahan antara C=C sehingga menghasilkan ikatan rangkap C=O [4] . Hasil dari degradasi ini tergantung pada jenis ikatan rangkap yang teroksidasi dan kondisi perlakuan.…”

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Degradasi Senyawa Imidakloprid Secara Advanced Oxidation Processes Dengan Penambahan Tio2-Anatase

2015

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Imidacloprid is active compounds in Confidor 200 SL with have toxical character. Degradation of Imidacloprid in Advanced Oxidation Processes (AOPs) method by using TiO 2 catalyst can reduce toxic level. Advanced Oxidation Processes (AOPs) method which is used is Sonolysis, Photolysis, and Ozonolisis. The result of sonolysis, Photolysis, and Ozonolysis measured by spectrophotometer UV-Vis with λ 400-600 nm, and than optimum degradation waste after addition of catalys measured by HPLC. The result of degradation of Imidacloprid 6 mg/L using sonolysis without addition catalys is more smallest from addition catalys which degradated in 60 minute, temperature 25±1 °C. At the same time with Photolysis methode for addition catalys we get the degradation is more biggest from addition catalys. Degradation percentage of imidacloprid without addition of TiO 2 -anatase reach is small from with addition of TiO 2 . Measure using HPLC for each methode we get more than one peak in chromatogram. It means there are other coumpounds in imidacloprid solution.

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Dialkyl Mesoxalates by Ozonolysis of Dialkyl Benzalmalonates: Dimethyl Mesoxalate

Abstract: Dialkyl mesoxalates by ozonolysis of dialkyl benzalmalonates: dimethyl mesoxalate product: dimethyl mesoxalate hydrate

Cited by 5 publications

References 23 publications

Novel Lactonization of Ethenetricarboxylate Derivatives: Intermolecular Trapping of Alkenes.

Novel Lactonization of Ethenetricarboxylate Derivatives: Intermolecular Trapping of Alkenes.

Stapled Peptides—A Useful Improvement for Peptide-Based Drugs

Degradasi Senyawa Imidakloprid Secara Advanced Oxidation Processes Dengan Penambahan Tio2-Anatase

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