Diagonal ear-lobe crease is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease

Çelık, Şükrü; Gedikli, Ömer; Kırış, Abdülkadir; Erem, Cihangir

doi:10.1016/j.atherosclerosis.2006.08.042

Cited by 52 publications

(52 citation statements)

References 19 publications

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“…Celik et al have reported a significant association between ELC and the carotid IMT in a population sample of middle-aged adults without known atherosclerotic disease. 3 In this regard, the present study also supports the association between ELC and carotid IMT. To the best of our knowledge, this is the first published report regarding the association between carotid IMT, carotid PS and ELC in an oriental population.…”

Section: Discussionsupporting

confidence: 86%

“…1,[9][10][11][12][13][14][15][16][17][18][19] While many studies have been reported regarding the relationship of ELC with CAD, very few have been reported on the correlation with atherosclerosis of the carotid artery. 2,3 Few have studied the correlation of ELC with carotid atherosclerosis, but they also have studied only the relationship with carotid IMT, not other indices of carotid artery ultrasonography such as PS and PN. Celik et al have reported a significant association between ELC and the carotid IMT in a population sample of middle-aged adults without known atherosclerotic disease.…”

Section: Discussionmentioning

confidence: 99%

“…While many studies have been reported regarding the relationship of ELC with CAD, very few have been reported regarding the correlation with atherosclerosis of the carotid artery. 2,3 The carotid artery intima-media thickness (IMT) is not only taken as one of the risk factors for cerebrovascular disease (CVD), but it is also considered as a reliable marker of systemic atherosclerosis. [4][5][6] This study has been designed in this regard, to study the prevalence of the ELC in relation to the carotid atherosclerosis, and to find out whether it can be used as a marker of carotid atherosclerosis and thus an indicator of future stroke.…”

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confidence: 99%

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Diagonal Ear-Lobe Crease is Correlated With Atherosclerotic Changes in Carotid Arteries

Shrestha

Ohtsuki

Nomura

et al. 2009

Circ J

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Background:The diagonal ear-lobe crease (ELC) is reported to be a marker of cardiovascular disease. Very few reports have assessed the relationship of ELC with atherosclerosis. This relationship is investigated here using a Japanese population. Methods and Results: A prospective cross-sectional study included 212 consecutive patients. Bilateral ear lobes were checked for the ELC and this was followed by carotid ultrasonography to measure the far wall common carotid artery intima-media thickness (CCA-IMT), plaque score (PS) and plaque number (PN). Patients with ELC had significantly higher carotid IMT than controls (0.90±0.24 vs 0.77±0.15, respectively, P<0.001). ELC presence correlated significantly with carotid IMT, PS, and PN (r=0.306, P<0.0001; r=0.198, P<0.008 and r=0.221, P<0.0001, respectively), and also with age, male sex and hypertension. ELC presence and absence in mild or no PS and moderate or severe PS subgroups was significant, with a chi-squared value of 7.59 (P<0.006). In multivariate regression analysis, ELC presence correlated with CCA-IMT independently. The odds ratio for the presence of ELC in patients with CCA-IMT of <0.8 mm vs patients with CCA-IMT of ≥0.8 mm (the median value) was 0.41 (95% confidence interval, 0.22-0.76). Conclusions:The present study showed an association between ELC and increased CCA-IMT, PS, and PN. (Circ J 2009; 73: 1945 -1949

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Diagonal Ear-Lobe Crease is Correlated With Atherosclerotic Changes in Carotid Arteries

Shrestha

Ohtsuki

Nomura

et al. 2009

Circ J

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“…Earlobe crease is a diagonal fold or wrinkle in the skin of the earlobe, whereas xanthelasmata and arcus corneae are cholesterol deposits on the eyelids and in the cornea, respectively. [17][18][19] Most studies confirm an association between earlobe crease and risk of cardiovascular disease [20][21][22][23][24] or death, 25 although some studies argue that this association is mainly attributable to an association between earlobe crease and increasing age. 26 We have recently shown that xanthelasmata and arcus corneae are associated with an increased risk of ischemic heart disease (IHD) and death independent of age and sex-and for xanthelasmata also independent of plasma lipid levels.…”

Section: Clinical Perspective On P 998mentioning

confidence: 99%

Visible Age-Related Signs and Risk of Ischemic Heart Disease in the General Population

et al. 2014

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Background-Cardiovascular disease is 1 of the most common age-related diseases, and also 1 of the most common causes of death in the general population. We tested the hypothesis that visible age-related signs associate with risk of ischemic heart disease (IHD), myocardial infarction (MI), and death in the general population, independent of chronological age. Methods and Results-10,885 individuals aged 20 to 93 years free of IHD were followed from 1976 through 1978 until June 2011 with 100% complete follow-up. During these 35 years of follow-up, 3401 participants developed IHD and 1708 developed MI. Presence of frontoparietal baldness, crown top baldness, earlobe crease, and xanthelasmata was associated with increased risk of IHD or MI after multifactorial adjustment for chronological age and well-known cardiovascular risk factors. The risk of IHD and MI increased stepwise with increasing number of age-related signs with multifactorially adjusted hazard ratios up to 1.40 (95% confidence interval, 1.20-1.62) for IHD and 1.57 (1.28-1.93) for MI, in individuals with 3 to 4 versus no age-related signs at baseline (P for trend <0.001). In all age groups in both women and men, absolute 10-year risk of IHD and MI increased with increasing number of visible age-related signs. Conclusions-Male pattern baldness, earlobe crease, and xanthelasmata-alone or in combination-associate with increased risk of ischemic heart disease and myocardial infarction independent of chronological age and other wellknown cardiovascular risk factors. This is the first prospective study to show that looking old for your age is a marker of poor cardiovascular health. (Circulation. 2014;129:990-998.)

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“…Celik et al found a relationship between ELC and IMT in a healthy population, but they only examined IMT. 11 Although IMT is a useful parameter for evaluating the early stage of atherosclerosis, PS and PN are more useful for evaluating advanced atherosclerosis. In Shrestha's report, the patients had various disease and thus, I consider their selection of these parameters to be reasonable.…”

Section: Article P 1945mentioning

confidence: 99%

Ear-Lobe Crease as a Marker of Carotid Artery Arthrosclerosis

Nagatsuka¹

2009

Circ J

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Diagonal ear-lobe crease is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease

Cited by 52 publications

References 19 publications

Diagonal Ear-Lobe Crease is Correlated With Atherosclerotic Changes in Carotid Arteries

Diagonal Ear-Lobe Crease is Correlated With Atherosclerotic Changes in Carotid Arteries

Visible Age-Related Signs and Risk of Ischemic Heart Disease in the General Population

Ear-Lobe Crease as a Marker of Carotid Artery Arthrosclerosis

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