Diagnostische Strategien bei rheumatischen Autoimmunerkrankungen

Abstract

In order to help the clinical rheumatologist set an early and precise diagnosis and plan a rational follow-up, a close collaboration between all parties involved in the diagnostic work-up must be established. Autoimmune serology plays a key role in achieving this goal by choosing test methods that are ideal from a clinical standpoint and by presenting results obtained in such a fashion that even less experienced clinicians can correctly use the information. Simple algorithms for test ordering and for the interpretation of laboratory findings are of great benefit in daily practice, but such tools must be mutually agreed upon by the laboratory and clinical scientists. A precise diagnosis and estimation of prognosis is instrumental for optimal decision making in the clinic, but this is too complicated to be left to chance due to the inappropriate use of information. Late or wrong decisions during follow-up lead to unnecessary suffering and far higher lifetime costs for chronic diseases such as those found in rheumatology.

The CytoBead assay – a novel approach of multiparametric autoantibody analysis in the diagnostics of systemic autoimmune diseases

“…While the former parameters point to inflammatory processes irrespective of their causes, disease-specific AAb can be seen as an important sign of the autoimmune pathogenesis. AAb can, therefore, serve as a benchmark for the diagnosis and therapy of SAD [3,4,6] . In the majority of known SAD, more than a few AAb with diagnostic and/or prognostic relevance can be detected, and their determination has been included in classification criteria Brought to you by | Kungliga Tekniska Högskolan Authenticated Download Date | 8/25/15 9:11 PM of corresponding SAD [7 -9] .…”

Der CytoBead-Assay – Eine neue Möglichkeit der multiparametrischen Autoantikörperanalytik bei systemischen Autoimmunerkrankungen

“…gewertet werden. AAK können daher richtungsweisend für die Diagnostik und Therapie von SAIE sein [3,4,6]. Bei der Mehrzahl der bekannten SAIE sind mehrere AAK mit diagnostischer und/oder prognostischer Relevanz nachweisbar und deren Bestimmung hat Eingang in die Klassifikationskriterien solcher SAIE gefunden [7][8][9].…”