Diagnostik und Therapie vesikovaginaler und ureterovaginaler Fisteln

Lang, I J; Fisch, Margit; Kluth, Luis A.

doi:10.1055/s-0043-125318

Cited by 4 publications

(1 citation statement)

References 37 publications

(58 reference statements)

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“…Different authors reported the use of both dyes for diagnostic procedures including: in vivo confocal laser endomicroscopy [37,38], in vivo microscopy to identify Barrett's esophagus [39], pathological changes in oral mucosa [40], colon [9], stomach [41], duodenum, upper gastrointestinal tract [41] and central airway, cervical tissue [35,42], cervix [35], sarcoma [43], urinary fistula [44], sentinel node (SN)'s, head and neck cancers [45], breast cancer [17], and gastrointestinal and thyroid surgery [10]. Apart from MB and PRO's ability to stain nuclei, the latter also stains non-specifically the membranes of adipocyte cells, making it possible to identify adipocytes without using a contrast agent [43].…”

Section: Preoperative and Intraoperative Use In Cardiac Surgerymentioning

confidence: 99%

Comparative Study Regarding the Properties of Methylene Blue and Proflavine and Their Optimal Concentrations for In Vitro and In Vivo Applications

et al. 2020

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Methylene blue and proflavine are fluorescent dyes used to stain nucleic acid from the molecular level to the tissue level. Already clinically used for sentinel node mapping, detection of neuroendocrine tumors, methemoglobinemia, septic shock, ifosfamide-induced encephalopathy, and photodynamic inactivation of RNA viruses, the antimicrobial, anti-inflammatory, and antioxidant effect of methylene blue has been demonstrated in different in vitro and in vivo studies. Proflavine was used as a disinfectant and bacteriostatic agent against many gram-positive bacteria, as well as a urinary antiseptic involved in highlighting cell nuclei. At the tissue level, the anti-inflammatory effects of methylene blue protect against pulmonary, renal, cardiac, pancreatic, ischemic-reperfusion lesions, and fevers. First used for their antiseptic and antiviral activity, respectively, methylene blue and proflavine turned out to be excellent dyes for diagnostic and treatment purposes. In vitro and in vivo studies demonstrated that both dyes are efficient as perfusion and tissue tracers and permitted to evaluate the minimal efficient concentration in different species, as well as their pharmacokinetics and toxicity. This review aims to identify the optimal concentrations of methylene blue and proflavine that can be used for in vivo experiments to highlight the vascularization of the skin in the case of a perforasome (both as a tissue tracer and in vascular mapping), as well as their effects on tissues. This review is intended to be a comparative and critical presentation of the possible applications of methylene blue (MB) and proflavine (PRO) in the surgical field, and the relevant biomedical findings from specialized literature to date are discussed as well.

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