Diagnostik des α‑Gal-Syndroms

Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules

“…AGS can be a challenging clinical diagnosis, as the main diagnostic method at the moment is based on a clinical history of delayed allergic reactions, especially associated with food allergies (i.e., pruritus, localized hives, or recurrent angioedema to anaphylaxis, urticaria, and gastrointestinal symptoms) and the measurement of IgE anti-α-Gal antibody levels 9 . Current findings suggest tick bites constitute one of the principal risks in the appearance of AGS 18,19 , a 20-fold or greater increase in IgE levels to α-Gal following a tick bite 19 , a history of tick bites in patients with AGS [20][21][22] , the existence of antibodies reactive to tick antigens in AGS patients 19 , and that anti-α-Gal IgE are strongly related to anti-tick IgE levels 19,23 but further studies are needed to assess which biomolecules are actually involved. In addition, another possible scenario is patients who present strong allergic reactions to tick bites and high levels of anti-α-Gal IgE antibodies but are tolerant to mammalian meat consumption 12 .…”

Anaphylaxis to drug excipients

“…BAT are also possible [ 20 ]. If these tests are negative, oral provocation tests can be performed, which may include challenge with beef or pork ± cofactors of summation anaphylaxis in addition to the original preparation [ 21 ].…”