Diagnostik des endolymphatischen Hydrops mit tieftonmodulierten DPOAE

Hirschfelder, Anke; Gossow-Müller-Hohenstein, E; Hensel, Johannes; Scholz, Günter; Mrowinski, Dieter

doi:10.1007/s00106-004-1171-4

HNO

2005

DOI: 10.1007/s00106-004-1171-4

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Diagnostik des endolymphatischen Hydrops mit tieftonmodulierten DPOAE

Anke Hirschfelder

E Gossow-Müller-Hohenstein

Johannes Hensel

et al.

Abstract: The registration of low-frequency modulated DPOAEs is comparable to the generally applied transtympanic electrocochleography in its diagnostic validity. The method is fast and non-invasive and could be applied to monitor the course of the disease.

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Cited by 10 publications

References 21 publications

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Rezidivierende Tiefton-Hörverluste ohne Schwindel – ein eigenes Krankheitsbild?

Schaaf¹,

Hesse²

2006

HNO

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We conclude from our observations that, although almost every patient with Menière's disease suffers from recurrent low-frequency hearing loss, only a few patients with recurrent hearing loss develop Menière's disease. However, many patients with low-frequency sensory hearing loss develop anxiety leading to psychogenic dizziness in fearful expectation of "imminent" Menière's disease. We found that 26% of the patients had persisting bilateral normacusis in the low-frequency ranges, while 34% had unilateral hearing loss that was sufficiently severe to affect their lives and 39%, bilateral hearing loss; however, none of the patients became completely deaf.

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Rezidivierende Tiefton-Hörverluste ohne Schwindel – ein eigenes Krankheitsbild?

Schaaf¹,

Hesse²

2006

HNO

View full text Add to dashboard Cite

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Low-frequency distortion product otoacoustic emission test compared to ECoG in diagnosing endolymphatic hydrops

Rotter

Weikert

Hensel

et al. 2007

Eur Arch Otorhinolaryngol

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Previous studies assumed that specific audiometric measures like low-frequency biasing were noninvasive and inexpensive techniques for diagnosing endolymphatic hydrops (EH). The aim of this study was to compare the results of low-frequency DPOAE (LF-DPOAE) with those of transtympanic electrocochleography (ECoG) in patients with Menière's disease (MD). The prospective study included 50 patients, 22 to 72 years old, who were diagnosed with Menière's disease according to the criteria laid down by the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) in 1995. LF-DPOAE and ECoG were performed on the same day after standard audiometry. Enlarged amplitude of summation potential to action potential ratio was used as the diagnostic criterion for EH. The results were compared to those of LF-DPOAE. In this audiometric examination we used the modulation index (MI) to detect EH if MI < 0.5. ECoG yielded a result in 46 of the 50 patients examined. An enlarged SP/AP ratio was found in 23 patients (50%). The results of 33 patients could be compared, i.e. assessable results in both tests. The two tests yielded the same results in 13 patients and different ones in 20 patients. ROC analysis and Mann-Whitney statistics showed no significant correlation between the two tests. With ECoG as the gold standard for verifying EH, we found that LF-DPOAE is not yet a suitable method for diagnosing EH.

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Multiple Indices of the ‘Bounce’ Phenomenon Obtained from the Same Human Ears

Drexl

Überfuhr

Weddell

et al. 2013

JARO

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Loud low-frequency sounds can induce temporary oscillatory changes in cochlear sensitivity, which have been termed the 'bounce' phenomenon. The origin of these sensitivity changes has been attributed to slow fluctuations in cochlear homeostasis, causing changes in the operating points of the outer hair cell mechanoelectrical and electro-mechanical transducers. Here, we acquired three objective and subjective measures resulting in a comprehensive dataset of the bounce phenomenon in each of 22 normal-hearing human subjects. We analysed the level and phase of cubic and quadratic distortion product otoacoustic emissions and the auditory thresholds before and after presentation of a low-frequency stimulus (30 Hz sine wave, 120 dB SPL, 90 s) as a function of time. In addition, the perceived loudness of temporary, tinnitus-like sensations occurring in all subjects after cessation of the low-frequency stimulus was tracked over time. The majority of the subjects (70 %) showed a significant, biphasic change of quadratic, but not cubic, distortion product otoacoustic emissions of about 3-4 dB. Eighty-six percent of the tested subjects showed significant alterations of hearing thresholds after low-frequency stimulation. Four different types of threshold changes were observed, namely monophasic desensitisations (the majority of cases), monophasic sensitisations, biphasic alterations with initial sensitisation and biphasic alterations with initial desensitisation. The similar duration of the three bounce phenomenon measures indicates a common origin. The current findings are consistent with the hypothesis that slow oscillations of homeostatic control mechanisms and associated operating point shifts within the cochlea are the source of the bounce phenomenon.

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Diagnostik des endolymphatischen Hydrops mit tieftonmodulierten DPOAE

Abstract: The registration of low-frequency modulated DPOAEs is comparable to the generally applied transtympanic electrocochleography in its diagnostic validity. The method is fast and non-invasive and could be applied to monitor the course of the disease.

Cited by 10 publications

References 21 publications

Rezidivierende Tiefton-Hörverluste ohne Schwindel – ein eigenes Krankheitsbild?

Rezidivierende Tiefton-Hörverluste ohne Schwindel – ein eigenes Krankheitsbild?

Low-frequency distortion product otoacoustic emission test compared to ECoG in diagnosing endolymphatic hydrops

Multiple Indices of the ‘Bounce’ Phenomenon Obtained from the Same Human Ears

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