Abstract:In ecotoxicology, toxicokinetic-toxicodynamic models are increasingly being used to relate toxicant concentration to survival. These have a toxicokinetic component that specifies a model for toxicant uptake and elimination and a toxicodynamic component that specifies a model for the relationship between internal body concentration of toxicant and the hazard rate. Often, the toxicodynamic model is a proportional hazards model and the data to evaluate the model is interval censored. We develop diagnostic methods… Show more
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