Diagnostics of Helicobacter pylori Infection in Patients with Peptic Ulcer Bleeding

Peitz, Ulrich; Leodolter, Andreas; Wex, Thomas; Schütze, D.; Wolle, K.; Welte, Tobias; Günther, Thomas; Schmidt, U; Malfertheiner, Peter

doi:10.1055/s-2004-812836

Cited by 14 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are conflicting results in the literature regarding its association. While some studies show a high prevalence of H. pylori infection in PPU patients, and its eradication preventing the relapse of ulcer, others show a low or complete lack of association, suggesting different pathogenesis for PPU [1,[6][7]. Because of these conflicting results and paucity of data, this study was undertaken to assess the role of H. pylori in patients with PPU.…”

mentioning

confidence: 99%

“…The incidence of perforated peptic ulcer (PPU) has only declined minimally despite the widespread use of Helicobacter pylori (H. pylori) eradicative agents. About 95% of the patients suffering from duodenal ulcers and 70-80% of the gastric ulcer patients are found to be H. pylori-positive [1]. Although the role of H. pylori is well known in peptic ulcer disease (PUD) etiology, its role in PPU is not well established [2][3][4][5].…”

mentioning

confidence: 99%

See 1 more Smart Citation

The Association Between Helicobacter Pylori and Perforated Gastroduodenal Ulcer

K¹,

Jayapal²,

Anandhi³

et al. 2020

Cureus

View full text Add to dashboard Cite

Background Although the role of Helicobacter pylori (H. pylori) is well known in peptic ulcer disease (PUD) etiology, its role in perforated peptic ulcer (PPU) is not well established. This study aimed to assess the role of H. pylori infection in patients with PPU and to compare it with its prevalence in patients with PUD. Methodology This prospective analytical study was conducted for two years. The study patients were classified into two groups: group I consisted of patients (n = 48) operated for PPU and group II were patients (n = 48) with PUD diagnosed by endoscopy. The study excluded patients with any previous anti-H. pylori treatment, gastric malignancy, conservative management of sealed PPU, and those with a diameter of perforation less than the diameter of endoscopic biopsy forceps. Blood samples were taken for H. pylori serology IgG (ELISA) test. The mucosal biopsy samples from both the groups were tested with a rapid urease test and modified Giemsa stain examination to detect H. pylori.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

The Association Between Helicobacter Pylori and Perforated Gastroduodenal Ulcer

K¹,

Jayapal²,

Anandhi³

et al. 2020

Cureus

View full text Add to dashboard Cite

show abstract

Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding

Neumann

Letelier

Rada

et al. 2013

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Non-invasive diagnostic tests forHelicobacter pyloriinfection

Best

Takwoingi

Siddique

et al. 2018

Cochrane Database of Systematic Reviews

153

130

View full text Add to dashboard Cite

In people without a history of gastrectomy and those who have not recently had antibiotics or proton ,pump inhibitors, urea breath tests had high diagnostic accuracy while serology and stool antigen tests were less accurate for diagnosis of Helicobacter pylori infection.This is based on an indirect test comparison (with potential for bias due to confounding), as evidence from direct comparisons was limited or unavailable. The thresholds used for these tests were highly variable and we were unable to identify specific thresholds that might be useful in clinical practice.We need further comparative studies of high methodological quality to obtain more reliable evidence of relative accuracy between the tests. Such studies should be conducted prospectively in a representative spectrum of participants and clearly reported to ensure low risk of bias. Most importantly, studies should prespecify and clearly report thresholds used, and should avoid inappropriate exclusions.

show abstract

Diagnostics of Helicobacter pylori Infection in Patients with Peptic Ulcer Bleeding

Cited by 14 publications

References 22 publications

The Association Between Helicobacter Pylori and Perforated Gastroduodenal Ulcer

The Association Between Helicobacter Pylori and Perforated Gastroduodenal Ulcer

Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding

Non-invasive diagnostic tests forHelicobacter pyloriinfection

Contact Info

Product

Resources

About