Diagnostics of Epigenetic Alterations in Hereditary and Oncological Disorders

Zaletaev, D. V.; Немцова, М. В.; Стрельников, В. В.; Бабенко, О. В.; Васильев, Е. В.; Zemlyakova, V. V.; Zhevlova, A. I.; Drozd, O. V.

doi:10.1023/b:mbil.0000023731.25512.fa

Cited by 7 publications

(2 citation statements)

References 16 publications

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“…To view the supplementary data that accompany this paper please visit the journal website at: www.futuremedicine.com/doi/full/ 10.2217/epi-2018-0213 614 Epigenomics (2019) 11 (6) future science group…”

Section: Supplementary Datamentioning

confidence: 99%

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Genome-Wide Methylotyping Resolves Breast Cancer Epigenetic Heterogeneity and Suggests Novel Therapeutic Perspectives

et al. 2019

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To provide a breast cancer (BC) methylotype classification by genome-wide CpG islands bisulfite DNA sequencing. Materials & methods: XmaI-reduced representation bisulfite sequencing DNA methylation sequencing method was used to profile DNA methylation of 110 BC samples and 6 normal breast samples. Intrinsic DNA methylation BC subtypes were elicited by unsupervised hierarchical cluster analysis, and cluster-specific differentially methylated genes were identified. Results & conclusion: Overall, six distinct BC methylotypes were identified. BC cell lines constitute a separate group extremely highly methylated at the CpG islands. In turn, primary BC samples segregate into two major subtypes, highly and moderately methylated. Highly and moderately methylated superclusters, each incorporate three distinct epigenomic BC clusters with specific features, suggesting novel perspectives for personalized therapy.

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Section: Supplementary Datamentioning

confidence: 99%

“…Aberrant DNA methylation is associated with wide spectrum of disease and is most pronounced in malignancies. It was suggested that detection of the tumor-specific patterns of aberrant DNA methylation might be useful for early cancer diagnostics, for differential diagnostics of malignancies, and as predictive and prognostic markers [4][5][6][7][8].…”

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confidence: 99%