Diagnostics and therapy of oral precancerous lesions

Hüllmann, M.; Kunkel, Martin; Reichert, Torsten E.

doi:10.1007/s12285-009-0102-5

Cited by 3 publications

(4 citation statements)

References 59 publications

(51 reference statements)

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“…Automated image analysis, DNA image cytometry and immunocytochemistry also provide additional support for cytological analyses. The gold standard for definitive diagnosis is still histopathological examination of a scalpel biopsy (Hullmann et al, 2010). In 2010 Brocklehurst et al showed in a Cochrane review that there is no robust evidence for adjunctive methods of screening, toluidine blue, fluorescence imaging and brush biopsy to be either included or excluded (Brocklehurst et al, 2010).…”

Section: Discussion and Mini Reviewmentioning

confidence: 99%

Fatal course of tonsillar squamous cell carcinoma associated with Fanconi anaemia: A mini review

Spanier¹,

Pohl

Giese

et al. 2012

Journal of Cranio-Maxillofacial Surgery

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Section: Discussion and Mini Reviewmentioning

confidence: 99%

Fatal course of tonsillar squamous cell carcinoma associated with Fanconi anaemia: A mini review

Spanier¹,

Pohl

Giese

et al. 2012

Journal of Cranio-Maxillofacial Surgery

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“…Almost 50 % of oral cancer patients die within 5 years after diagnosis [24,38], and survivors have to accept significant disfigurement, limitation of oral function, and, accordingly, a highly impaired quality of life [13,38]. The 5-year survival rate varies according to tumor size, whereas prognosis is significantly influenced by the presence or absence of cervical lymph node metastases [30].…”

Section: Introductionmentioning

confidence: 99%

“…Although early squamous cell carcinomas are often occult, well-known clinical lesions are present [20]. In over 90 %, oral squamous cell carcinomas arise from oral dysplasia, clinically identifiable as leuko-and erythroplakia [8,13].…”

Section: Introductionmentioning

confidence: 99%

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Autofluorescence imaging in recurrent oral squamous cell carcinoma

Scheer

Fuss

Derman

et al. 2015

Oral Maxillofac Surg

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The survival of patients with oral cancer is decreased by locoregional recurrence after an initial multimodal treatment. In order to identify lesions in the oral cavity for a possible recurrence, clinical evaluation as well as MRI or CT scanning is advised. The evaluation of mucosa lesions is hampered by changes related to radio- and chemotherapy as well as reconstruction with tissue flaps. Several techniques for easier identification of tissue abnormalities in the oral cavity have been advocated as adjuncts in order to facilitate identification. Especially methods using altered tissue fluorescence have gained much interest during the last decade. The aim of our prospective study was to evaluate fluorescence properties of undiagnosed mucosa lesions with the VELscope device in patients with multimodal treated oral cancer prior to histological confirmation. In total, 41 patients with a history of oral squamous cell carcinomas (OSCC) (19 females and 22 males) with undiagnosed mucosa lesions where included in the study. After clinical evaluation, examination and documentation using the VELscope® device were performed. Then, an incisional biopsy was performed. An autofluorescence loss indicating a malignant or dysplastic mucosa condition could be detected in six patients (14.6 %); however, only one OSCC and one SIN revealed a complete autofluorescence loss. In four patients, OSCC was present in lesions with retained autofluorescence. Sensitivity and specificity for the VELscope® examination to identify malignant oral lesions by autofluorescence were 33.3 and 88.6 %, respectively. The positive and negative predictive values were 33.3 and 88.6 %, respectively. No statistical correlation between gender and lesion appearance versus autofluorescence loss could be detected. In contrast to mucosa lesions in patients with no prior treatment, the autofluorescence evaluation with the VELscope reveals no additional information in our analysis. Accordingly, invasive biopsies as gold standard are still needed to get sufficient evidence regarding potential malignancy in patients after multimodal treatment for oral cancer.

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Aktuelle Konzepte zur Früherkennung, Diagnostik und Therapie oraler Plattenepithelkarzinome

Hüllmann

Reichert

2011

Bundesgesundheitsbl.

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This article offers a short review of risk factors, oral precancerous conditions, and oral precancerous lesions which may cause oral squamous carcinoma. Current diagnostic methods and multidisciplinary strategies for the early detection and appropriate therapy of oral squamous carcinomas are discussed. Close cooperation of oral and maxillofacial surgeons, head and neck surgeons, radiotherapists, and oncologists is essential for the effective therapy of oral squamous carcinomas.

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Diagnostics and therapy of oral precancerous lesions

Cited by 3 publications

References 59 publications

Fatal course of tonsillar squamous cell carcinoma associated with Fanconi anaemia: A mini review

Fatal course of tonsillar squamous cell carcinoma associated with Fanconi anaemia: A mini review

Autofluorescence imaging in recurrent oral squamous cell carcinoma

Aktuelle Konzepte zur Früherkennung, Diagnostik und Therapie oraler Plattenepithelkarzinome

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