Diagnóstico pré-natal de displasia camptomélica: relato de caso

Coutinho, Tadeu; Coutinho, Conrado Milani; Coutinho, Larissa Milani

doi:10.1590/s0100-72032008000500008

Cited by 2 publications

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“…In patients with VaIN 3 the rate of progression to invasive disease was significantly higher when compared with patients with VaIN 2 (15.4% vs 1.4%, p<0.0001). In other studies, even higher rates of progression of vaginal HSIL to invasive cancer were noted, ranging from 17% to 20% 66,115 …”

Section: Methodsmentioning

confidence: 74%

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The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) Consensus Statement on the Management of Vaginal Intraepithelial Neoplasia

Kesic,

Carcopino,

Preti

et al. 2023

J Low Genit Tract Dis

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The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) developed consensus statements on pre-invasive vulvar lesions in order to improve the quality of care for patients with vaginal intraepithelial neoplasia (VaIN). The management of VaIN varies according to the grade of the lesion: VaIN 1 (low grade vaginal squamous intraepithelial lesions (SIL)) can be subjected to follow-up, while VaIN 2–3 (high-grade vaginal SIL) should be treated. Treatment needs individualization according to the patient’s characteristics, disease extension and previous therapeutic procedures. Surgical excision is the mainstay of treatment and should be performed if invasion cannot be excluded. Total vaginectomy is used only in highly selected cases of extensive and persistent disease. Carbon dioxide (CO 2 ) laser may be used as both an ablation method and an excisional one. Reported cure rates after laser excision and laser ablation are similar. Topical agents are useful for persistent, multifocal lesions or for patients who cannot undergo surgical treatment. Imiquimod was associated with the lowest recurrence rate, highest human papillomavirus (HPV) clearance, and can be considered the best topical approach. Trichloroacetic acid and 5-fluorouracil are historical options and should be discouraged. For VaIN after hysterectomy for cervical intraepithelial neoplasia (CIN) 3, laser vaporization and topical agents are not the best options, since they cannot reach epithelium buried in the vaginal scar. In these cases surgical options are preferable. Brachytherapy has a high overall success rate but due to late side effects should be reserved for poor surgical candidates, having multifocal disease, and with failed prior treatments. VaIN tends to recur and ensuring patient adherence to close follow-up visits is of the utmost importance. The first evaluation should be performed at 6 months with cytology and an HPV test during 2 years and annually thereafter. The implementation of vaccination against HPV infection is expected to contribute to the prevention of VaIN and thus cancer of the vagina. The effects of treatment can have an impact on quality of life and result in psychological and psychosexual issues which should be addressed. Patients with VaIN need clear and up-to-date information on a range of treatment options including risks and benefits, as well as the need for follow-up and the risk of recurrence.

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Section: Methodsmentioning

confidence: 74%

“…In other studies, even higher rates of progression of vaginal HSIL to invasive cancer were noted, ranging from 17% to 20%. 66 , 115 …”

Section: Methodsmentioning

confidence: 99%

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) Consensus Statement on the Management of Vaginal Intraepithelial Neoplasia

Kesic,

Carcopino,

Preti

et al. 2023

J Low Genit Tract Dis

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“…14 A presença de achados nesse exame sugestivos da síndrome indica a realização da cariotipagem fetal para a confirmação diagnóstica e estimativa do prognóstico do concepto. 15 A DC tem sua manifestação relacionada à mutação no gene SOX9, na região do cromossomo 17q24, que é responsável pela diferenciação de células mesenquimais em linhagem condrogênica. 16,17 O gene também é intimamente relacionado à formação do osso endocondral derivado da crista neural no 1º , 2º, 3º, 4º arcos branquiais.…”

Section: Discussionunclassified

Manifestações otorrinolaringológicas na Displasia Campomélica: relato de caso.

Polanski,

Ferdinando,

Fukumoto

et al. 2022

BioSCIENCE

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Diagnóstico pré-natal de displasia camptomélica: relato de caso

Cited by 2 publications

References 0 publications

Manifestações otorrinolaringológicas na Displasia Campomélica: relato de caso.

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