Diagnóstico etiológico de enfermidades do sistema nervoso central de equinos no Estado de Minas Gerais, Brasil

Costa, Érica Azevedo; Rosa, Roberto; Oliveira, T.S.; Furtini, Ronaldo; Júnior, Antônio Augusto Fonseca; Santos, Renato L.

doi:10.1590/1678-6765

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…Similarly, Costa et al (2015) found conflicting results between these tests using brain material from the equine species. Concordance between FAT and MIT was excellent for both cattle (0.97) and horses (0.94).…”

Section: Resultsmentioning

confidence: 99%

Results of laboratory diagnosis of rabies in herbivores (cattle and horses): a retrospective study

Barrosa¹,

Langoni

Victória³

et al. 2018

Braz. J. Vet. Med.

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Rabies is a zoonosis of extreme importance to public health. Specifically in herbivores it causes economic losses, considering its lethality. The diagnosis provides information to describe the epidemiology of the disease in the regional study. For this purpose, a survey of Central Nervous System (CNS) materials, received for diagnosis in the Center-West region of the State of São Paulo, by the Zoonosis Diagnostic Service (SDZ), Faculdade de Medicina Veterinária e Zootecnia (FMVZ)-UNESP-Botucatu-SP. In the period from 2001 to 2015, a total of 643 samples were analyzed, being 489 (76.05%) of the bovine species, with 68 (13.9%) positive samples and 154 (23.95%) of the equine species with 17 (11.3%) positive. For the analyzed bovine samples, sensitivity and specificity values of the fluorescent antibody test (FAT) were 88.24 and 99.52% respectively and for equines, 47.06 and 100.0%. The frequency of samples received by species, month, and year and the results of the diagnostic tests recommended by the World Health Organization (WHO), fluorescent antibody test (FAT) and the mouse inoculation test (MIT), were analysed.

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Section: Resultsmentioning

confidence: 99%

Results of laboratory diagnosis of rabies in herbivores (cattle and horses): a retrospective study

Barrosa¹,

Langoni

Victória³

et al. 2018

Braz. J. Vet. Med.

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“…Viremia persists for at least 14 days, which is a prerequisite for EHM, allowing the transport of the virus to the CNS, as well as the risk factors that determine its occurrence, where infection of endothelial cells occurs, but the mechanism underlying CNS endothelial infection is unknown, as are the risk factors that determine its occurrence, initiating an inflammatory cascade, vasculitis, microthrombosis and extravasation of mononuclear cells, resulting in perivascular cuffing and local hemorrhage. 3,1 .…”

Section: Theme Summarymentioning

confidence: 99%

“…The most common clinical signs are ataxia and flaccid paresis of the hind limbs. 2,6,1 , in addition to hypotonia of the tail and anus, and urinary incontinence 2,6,5 .…”

Section: Theme Summarymentioning

confidence: 99%

Neurological Syndrome Due to Equine Herpes Virus

Anjos,

Costa

2024

JASR

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“…Um levantamento da raiva equina no Piauí, entre 2007 a 2011, revelou 2,8% (1/35) de casos positivos [15]. Por outro lado, em Minas Gerais, Costa et al [4] demonstraram que, entre 2009 a 2011, houve 21,7% (47/217) de equinos positivos para raiva pela técnica de Imunofluorescência direta (IFD) e prova biológica. Na Paraíba, entre 2002 a 2008 foram verificados 6,9% (11/159) casos positivos dentre os equinos encaminhados para atendimento veterinário [13].…”

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Equine Rabies in the Southern Region of Piauí State

Schwarz

Barreto²,

Branco

et al. 2020

Acta Scientiae. Vet.

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Background: Rabies is an infectious disease that is important in the "One Health" worldwide with high lethality rate. The etiological agent is a neurotropic virus, genus Lyssavirus, transmitted mainly through the saliva of infected animals. For equines, the bite of hematophagous bats is the main source of infection. Piauí is an important state for equestrian sports and the increase in the number of horses with neurological clinical signs without diagnosis has increased in recent years. In this context, the aim of this study is to report to the scientific community a confirmed case of equine rabies in the Santa Luz county, Southernmost state of Piauí, Brazil.Case: A 3-year-old female non-defined breed horse, was admitted to the Hospital Veterinário da Universidade Federal do Piauí (UFPI/CPCE). The equine had difficulty walking 2 days ago, in the panoramic inspection was restless and disoriented in the paddock. Rectal temperature of 38.2oC, heart rate of 60 bpm, respiratory rate of 40 mpm, congested mucosa and dyspnea were verified. With the progression of the neurological signals, it positioned itself in a lateral decubitus with pedaling movements, hyperesthesia, dysphagia and paralysis of the hindlimbs. The clinical suspicion was rabies and the Agência de Defesa Agropecuária do Piauí (ADAPI) was communicated to euthanize the animal and collect samples for diagnosis in accordance with official standards of the Ministério da Agricultura, Pecuária e Abastecimento (MAPA). At necropsy, there was slight brain hyperemia, with no other significant organ changes. Fragments of the cerebellum, cortex, hippocampus and spinal cord were collected and sent at a temperature of 4oC to perform the Direct Immunofluorescence (DIF) assay. Samples for histopathology were not collected because they do not include assay for confirmatory diagnosis of rabies. The DIF technique with antigen-labeled antibodies were performed in the imprint lamina of these fragments. The fragments were treated according to specific protocol. The results were negative for DIF in the collected equine fragments. For complementary exam, the samples were homogenized, clarified and inoculated intracranial in BALB/C mice, being observed for up to 30 days. The samples were positive after the bioassay.Discussion: Piauí is a state with great equestrian activity that expose the animals to the risks of transmission of infectious diseases. Among these diseases, rabies is important for affecting horses, but also humans (veterinarians and owners). In the present report, the equine showed clinical signs of furious rabies for a short period, rapidly evolving to paralytic form. This clinical aspect must be carefully evaluated by the veterinarian, in order to avoid false clinical suspicions such as tetanus or other non-infectious diseases. The official diagnosis of the rabies is DIF technique, with high sensitive (80-100%). According to the results of the DIF technique, it was possible to confirm the clinical suspicion of rabies in mice previously inoculated with emulsion of fragments of the equine central nervous system (CNS). This fact demonstrates that in negative results for CNS samples from the horse, the bioassay increases the sensitivity of the test and avoids false negative diagnoses. Thus, it was possible to prove that rabies is affecting the equines in the southern region of Piauí state and alerts the breeders and the community to intensify surveillance and control of the hematophagous bats. For the authors, this is the first scientific report of rabies in the region studied.

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Diagnóstico etiológico de enfermidades do sistema nervoso central de equinos no Estado de Minas Gerais, Brasil

Cited by 7 publications

References 22 publications

Results of laboratory diagnosis of rabies in herbivores (cattle and horses): a retrospective study

Results of laboratory diagnosis of rabies in herbivores (cattle and horses): a retrospective study

Neurological Syndrome Due to Equine Herpes Virus

Equine Rabies in the Southern Region of Piauí State

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