Diagnóstico de endocrinopatía congénita en neonatos con ictericia prolongada e hipoglucemia

Braslavsky, Débora; Keselman, Ana; Chiesa, Ana; Bergadá, Ignacio

doi:10.1016/j.anpedi.2011.08.011

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Hypoglycaemia, generally serious, can occur in the first days, but less severe episodes may not manifest until a stressful situation occurs [2]. In our case, the possible relationship with rhinovirus infection and fever as a situation that triggered imbalance can be questioned.…”

mentioning

confidence: 79%

Liver dysfunction and hypoglycaemia as presentations of hypopituitarism in a child

Fonseca

Magalhães

Teixeira

et al. 2021

Endokrynologia Polska

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mentioning

confidence: 79%

Liver dysfunction and hypoglycaemia as presentations of hypopituitarism in a child

Fonseca

Magalhães

Teixeira

et al. 2021

Endokrynologia Polska

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“…This may result in recurrent hypoglycemia and acute adrenal insufficiency with impairment of growth and neurodevelopment [2, 5, 6]. Specific symptoms are not usually observed in CCH, and even in those cases where some unspecific clinical findings such as hypoglycemia or cholestasis appear, CCPHD may remain unrecognized during the neonatal period [7]. …”

Section: Introductionmentioning

confidence: 99%

Pilot Neonatal Screening Program for Central Congenital Hypothyroidism: Evidence of Significant Detection

Braslavsky¹,

Méndez

Prieto

et al. 2017

Horm Res Paediatr

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Background/Aim: Congenital hypothyroidism (CH) is a heterogeneous entity. Neonatal screening programs based on thyrotropin (TSH) determination allow primary CH diagnosis but miss central CH (CCH). CCH causes morbidity, alerts to other pituitary deficiencies, and is more prevalent than previously thought. We aimed at developing a pilot neonatal screening program for CCH detection. Patients and Methods: A prospective 2-year pilot neonatal screening study based on simultaneous dried blood specimen TSH and thyroxine (T₄) measurements was implemented in term newborns aged 2–7 days. Those with T₄ ≤4.5 µg/dL (–2.3 SDS) and TSH <10 mIU/L were recalled (suspicious of CCH) and underwent clinical and biochemical assessment performed by expert pediatric endocrinologists. Results: A total of 67,719 newborns were screened. Primary CH was confirmed in 24 (1: 2,821). Forty-four newborns with potential CCH were recalled (recall rate 0.07%) at a mean age of 12.6 ± 4.8 days. In this group, permanent CCH was confirmed in 3 (1: 22,573), starting L-T₄ treatment at a mean age of 12.3 ± 6.6 days; 14 boys showed T₄-binding globulin deficiency (1: 4,837); 24 had transient hypothyroxinemia (21 non-thyroidal illness and 3 healthy); and 3 died before the confirmation stage. According to initial free T₄ measurements, CCH patients had moderate hypothyroidism. Conclusions: Adding T₄ to TSH measurements enabled the identification of CCH as a prevalent condition and contributed to improving the care of newborns with congenital hypopituitarism and recognizing other thyroidal disorders.

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Growth, development, puberty and adult height of patients with congenital multiple pituitary hormone deficiencies

Haim-Pinhas

Kauli

Lilos

et al. 2016

Growth Hormone & IGF Research

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Diagnóstico de endocrinopatía congénita en neonatos con ictericia prolongada e hipoglucemia

Cited by 4 publications

References 21 publications

Liver dysfunction and hypoglycaemia as presentations of hypopituitarism in a child

Liver dysfunction and hypoglycaemia as presentations of hypopituitarism in a child

Pilot Neonatal Screening Program for Central Congenital Hypothyroidism: Evidence of Significant Detection

Growth, development, puberty and adult height of patients with congenital multiple pituitary hormone deficiencies

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