“…Despite constant efforts and significant advances in research and development of new chemotherapeutic agents, the recurrence of disease due to tumor heterogeneity, resistance to chemotherapeutic agents, adverse reactions, toxicity and permanent damage caused by these treatments remain major problems and challenges in the search for cures (Zellmer et al, 2014;Zhao, 2016). Therefore, the search for new therapies that are more efficient, less toxic and safer is extremely important (Alvez, 2012;Perez, 2012;Brasil, 2015).…”