Diagnostic yield of fluoroscopy-guided transbronchial biopsy in peripheral lung lesion: Adequacy of transbronchial sample for tumor genotyping

Baglioni, Stefano; Cicchitto, Gaetano; Mezzasalma, Fabrizio; Scoscia, Elvio; Dottorini, Maurizio

doi:10.1183/13993003.congress-2016.pa4681

Cited by 1 publication

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“…Furthermore, it can reach many different thoracic nodal stations compared with other diagnostic techniques, also with the concomitant use of the echobronchoscope through the esophagus [ 22 ]. On the other hand, when the pathology involves primarily the lung parenchyma, the endoscopic tool we have is represented by the TBB with different guide systems and instruments (fluoroscopy, radial EBUS, thin and ultrathin scopes, lung navigation systems): this specific technique has evolved through years and has reached higher accuracy also for more peripheral and smaller lung lesion, with an excellent safety profile [ 23 , 24 , 25 ]. Focusing on the other procedures used, MT is another established endoscopic technique with a high diagnostic yield and an excellent safety profile [ 26 ], especially if compared with other diagnostic techniques [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Pattern Identification of Intrathoracic Malignant Melanoma Metastasis: A Retrospective Single Center Analysis

et al. 2022

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The lung is a frequent site of secondary malignancies. Melanoma is a malignant tumor originating from melanocytes, that accounts for the majority of death related to skin cancers. In advanced stages, it can also present with intrathoracic metastasis, particularly in the lungs, but infrequent intrathoracic manifestations are possible. A retrospective analysis of the cases referred to the pulmonary endoscopy unit of the hospital of Reggio Emilia in the last 10 years (since December 2012) was carried out, discovering 17 cases of melanoma metastasis with thoracic localizations, either with or without a diagnosis of primary melanoma. Four repetitive patterns of clinical-radiological presentation have been identified and described through the same number of paradigmatic clinical cases: nodal involvement (35%), lung mass(es) (41%), diffuse pulmonary involvement (12%), and pleural involvement (12%). These different presentations imply the use of different diagnostic techniques, with an overall high diagnostic yield (87.5%). Finally, a brief analysis of survival based on the pattern of presentation has been performed, finding no statistically significant differences between the four groups at metastasis diagnosis (p-value = 0.06, median survival of respectively 54, 8, 9, and 26 months from metastasis diagnosis), while there is a significant difference considering patients with lung involvement versus nodal/pleural involvement (p = 0.01).

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